Reactome | p-Y397-PTK2 [cytosol]

p-Y397-PTK2 [cytosol]

Stable Identifier

R-HSA-354068

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p-Y397-FAK1, auto phosphorylated FAK 1

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Locations in the PathwayBrowser

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Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHB-mediated forward signaling (Homo sapiens)
        
        PTK2 autophosphorylates at Y397 (Homo sapiens)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Recruitment of p190RhoGEF to p-FAK (Homo sapiens)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        p190RhoGEF exchanges GTP for GDP on RHOA, activating it (Homo sapiens)
        
        EFNBs:p-EPHBs:p-Y397-PTK2:ARHGEF28 [plasma membrane] (Homo sapiens)
        
        EFNBs:p-EPHBs:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
    - NCAM signaling for neurite out-growth (Homo sapiens)
      - Phosphorylation of FAK by Src kinase (Homo sapiens)
        
        pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
      - Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
        
        pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
    - Netrin-1 signaling (Homo sapiens)
      - DCC mediated attractive signaling (Homo sapiens)
        
        Activation of Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Activation of Rac1 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        DCC interacting NCK-1 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Phosphorylation of DCC by Fyn (Homo sapiens)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Phosphorylation of FADK1 (Homo sapiens)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Recruitment of ABLIM to the plasma membrane (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP:ABLIM [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        Recruitment of Src and Fyn to DCC:FADK1 (Homo sapiens)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        RhoGTPase GEF's recruited to DCC (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2 [plasma membrane] (Homo sapiens)
        
        p-Y397-PTK2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q05397 PTK2

Gene Names

PTK2, FAK, FAK1

Chain

initiator methionine:1, chain:2-1052

Reference Genes

BioGPS Gene:5747 PTK2

CTD Gene:5747 PTK2

dbSNP Gene:5747 PTK2

ENSEMBL:ENSG00000169398 PTK2

HGNC:9611 PTK2

KEGG Gene (Homo sapiens):5747 PTK2

Monarch:5747 PTK2

NCBI Gene:5747 PTK2

OMIM:600758 PTK2

UCSC:Q05397 PTK2

Reference Transcript

Other Identifiers

0000670044

0002480025

11716373_a_at

11716374_s_at

11747793_a_at

207821_s_at

208820_at

312_s_at

3156306

3156308

3156309

3156310

3156313

3156315

3156322

3156324

3156328

3156338

3156339

3156342

3156345

3156357

3156358

3156360

3156362

3156366

3156373

3156375

3156377

3156387

3156388

3156392

3156393

3156396

3156397

3156400

3156402

3156404

3156410

3156420

3156425

3156435

3156457

3156464

3156465

36117_at

52392_s_at

5747

8153223

A_23_P22096

A_23_P324679

A_23_P72050

GE79453

GE85906

GO:0000003

GO:0000165

GO:0000166

GO:0000226

GO:0000902

GO:0001525

GO:0001568

GO:0001570

GO:0001725

GO:0001764

GO:0001890

GO:0001932

GO:0001934

GO:0002376

GO:0003007

GO:0003674

GO:0003779

GO:0004672

GO:0004713

GO:0004715

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0005925

GO:0005938

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006914

GO:0006950

GO:0007010

GO:0007097

GO:0007155

GO:0007165

GO:0007172

GO:0007173

GO:0007179

GO:0007229

GO:0007275

GO:0007411

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008360

GO:0008432

GO:0009056

GO:0010507

GO:0010594

GO:0010613

GO:0010632

GO:0010763

GO:0014068

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016324

GO:0016740

GO:0018108

GO:0019899

GO:0019901

GO:0019903

GO:0021955

GO:0022408

GO:0022607

GO:0030010

GO:0030027

GO:0030054

GO:0030154

GO:0030155

GO:0030198

GO:0030335

GO:0033628

GO:0034330

GO:0038007

GO:0038083

GO:0038096

GO:0040007

GO:0040011

GO:0042127

GO:0042169

GO:0043066

GO:0043087

GO:0043167

GO:0043197

GO:0043226

GO:0043231

GO:0043542

GO:0043552

GO:0045667

GO:0045860

GO:0046621

GO:0046777

GO:0048010

GO:0048013

GO:0048646

GO:0048856

GO:0048870

GO:0050771

GO:0051493

GO:0051893

GO:0051897

GO:0051964

GO:0060396

GO:0065003

GO:0071560

GO:0090303

GO:1900024

GO:2000060

GO:2000811

Hs.740.1.S2_3p_at

Hs.740.1.S2_3p_x_at

ILMN_1676305

ILMN_1714364

PH_hs_0025321

g5032000_3p_a_at

Participant Of

hasComponent

Other forms of this molecule

p-Y194,Y397,Y576,Y577-PTK2 [cytosol]

p-Y194,Y397-PTK2 [cytosol]

pY-PTK2 [cytosol]

PTK2(773-1052) [cytosol]

PTK2(1-772) [cytosol]

p-5Y-PTK2 [cytosol]

p-5Y,S732-PTK2 [cytosol]

p-6Y,S732-PTK2 [cytosol]

PTK2 [cytosol]

p-6Y-PTK2 [cytosol]

Inferred To

phospho-Ptk2 [cytosol] (Mus musculus)

phospho-Ptk2 [cytosol] (Rattus norvegicus)

Ghost homologue of p-Y397-PTK2 [cytosol] (Drosophila melanogaster)

Ghost homologue of p-Y397-PTK2 [cytosol] (Sus scrofa)

phospho-PTK2 [cytosol] (Canis familiaris)

phospho-kin-32 [cytosol] (Caenorhabditis elegans)

phospho-ptk2 [cytosol] (Xenopus tropicalis)

phospho-p-Y397-PTK2 [cytosol] (Bos taurus)

phospho-p-Y397-PTK2 [cytosol] (Gallus gallus)

phospho-ptk2ab [cytosol] (Danio rerio)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016869162.1, NP_722560.1, NP_001186578.1

ZINC - World Drugs

FAK1_HUMAN

OpenTargets

ENSG00000169398

ZINC - FDA approved

FAK1_HUMAN

ZINC - Substances

FAK1_HUMAN

ZINC - Biogenic

FAK1_HUMAN

ZINC target

Q05397

PRO

Q05397

PDB

2ETM, 3PXK, 4Q9S, 4EBV, 4GU6, 6LES, 4NY0, 1MP8, 4K9Y, 4I4F, 4K8A, 1OW8, 6I8Z, 4KAO, 4I4E, 1OW7, 2IJM, 1OW6, 3S9O, 4KAB, 4EBW, 1K05, 3BZ3, 1K04, 3B71, 4GU9

ZINC - Investigational

FAK1_HUMAN

ZINC - Metabolites

FAK1_HUMAN

HPA

ENSG00000169398-PTK2

GeneCards

Q05397

Ensembl

ENSP00000429474, ENST00000395218, ENST00000340930, ENSP00000429911, ENSP00000378644, ENST00000521059, ENST00000522684, ENSG00000169398, ENSP00000341189

ZINC - Predictions - Purchasable

FAK1_HUMAN

HMDB Protein

HMDBP01281

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.922	8
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.91	17
UniProt:P04637 TP53	27	TP53 [cytosol] (R-HSA-8869337) Unfolded TP53 [cytosol] (R-HSA-6813797) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) SUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) Me1-K372,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805719) Me2-K373-TP53 [nucleoplasm] (R-HSA-6805759) p-S15,S20,Me-R333,Me2-R335,R337-TP53 [nucleoplasm] (R-HSA-6804378) MeK-370,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222226) Me-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-3222124) Me2K-370,382-TP53 [nucleoplasm] (R-HSA-3222242) Ac-K120,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805656) Ac-K120,K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6805631) Ac-K382,p-S15,S20-TP53 [nucleoplasm] (R-HSA-5628868) p-S15,S20,S392-TP53 [nucleoplasm] (R-HSA-6805053) p-T55-TP53 [nucleoplasm] (R-HSA-6805400) p-S15,S33,S46-TP53 [nucleoplasm] (R-HSA-6805268) p-S315-TP53 [nucleoplasm] (R-HSA-6805106) p-S15,S20,S269,T284-TP53 [nucleoplasm] (R-HSA-6805133) p-S15,S392-TP53 [nucleoplasm] (R-HSA-3222015) p-S37-TP53 [nucleoplasm] (R-HSA-3239022) p-S15,S20,S46-TP53 [nucleoplasm] (R-HSA-6798369) PolyUb,p-S15,S20-TP53 [nucleoplasm] (R-HSA-6804446) PolyUb-TP53 [nucleoplasm] (R-HSA-6793679) PolyUb-TP53 [cytosol] (R-HSA-6793681) p-S15,S20-TP53 [nucleoplasm] (R-HSA-69683) p-S15-TP53 [nucleoplasm] (R-HSA-69507) TP53 [nucleoplasm] (R-HSA-69488)	0.761	13
UniProt:P05480 Src	12	phospho-Src [cytosol] (R-MMU-377592) Src [cytosol] (R-MMU-191648) phospho-Src [plasma membrane] (R-MMU-1810408) phospho-Src [plasma membrane] (R-MMU-377598) Src [plasma membrane] (R-MMU-65043) Src [cytosol] (R-MMU-418782) phospho-Src [plasma membrane] (R-MMU-112331) Src [plasma membrane] (R-MMU-8876922) MyrG-p-Y424-Src [plasma membrane] (R-MMU-9011258) Activated Src [nucleoplasm] (R-MMU-8937700) phospho-Src [cytosol] (R-MMU-8964276) Src [cytosol] (R-MMU-9628701)	0.683	5
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.667	4
UniProt:Q9H3S7 PTPN23	1	PTPN23 [nucleoplasm] (R-HSA-9008924)	0.639	4
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.635	3
UniProt:Q92569 PIK3R3	2	K63polyUb-PIK3R3 [cytosol] (R-HSA-3080574) PIK3R3 [cytosol] (R-HSA-205223)	0.632	3
UniProt:P56945 BCAR1	4	p-Y12-BCAR1 [cytosol] (R-HSA-5218739) p-Y-BCAR1 [cytosol] (R-HSA-372645) p-Y165,Y664-BCAR1 [cytosol] (R-HSA-8848723) BCAR1 [cytosol] (R-HSA-201625)	0.589	2
UniProt:P78396 CCNA1	3	CCNA1 [cytosol] (R-HSA-157446) PolyUb-CCNA1 [nucleoplasm] (R-HSA-6783068) CCNA1 [nucleoplasm] (R-HSA-68891)	0.589	2
UniProt:P04626 ERBB2	117	ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-6Y-ERBB2 E693K [plasma membrane] (R-HSA-9665871) p-6Y-ERBB2 R677L [plasma membrane] (R-HSA-9665864) p-6Y-ERBB2 Q709L [plasma membrane] (R-HSA-9665865) p-6Y-ERBB2 G660D [plasma membrane] (R-HSA-9665866) p-6Y-ERBB2 G660R [plasma membrane] (R-HSA-9665878) p-6Y-ERBB2 V659K [plasma membrane] (R-HSA-9665863) p-6Y-ERBB2 V659E [plasma membrane] (R-HSA-9665874) ERBB2 R678Q [plasma membrane] (R-HSA-9665756) ERBB2 S653C [plasma membrane] (R-HSA-9665754) ERBB2 R677L [plasma membrane] (R-HSA-9665759) ERBB2 G660R [plasma membrane] (R-HSA-9665768) ERBB2 V659E [plasma membrane] (R-HSA-9665752) ERBB2 G660D [plasma membrane] (R-HSA-9665753) ERBB2 V659K [plasma membrane] (R-HSA-9665769) ERBB2 Q709L [plasma membrane] (R-HSA-9665770) ERBB2 E693K [plasma membrane] (R-HSA-9665761) p-6Y-ERBB2 R678Q [plasma membrane] (R-HSA-9665876) p-6Y-ERBB2 S653C [plasma membrane] (R-HSA-9665875) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) ERBB2 [plasma membrane] (R-HSA-372889) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.589	2
UniProt:O43294 TGFI1			0.573	2
UniProt:P07948 LYN	5	LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) p-Y396-LYN [plasma membrane] (R-HSA-2454229) p-Y397-LYN [cytosol] (R-HSA-8942608) LYN [plasma membrane] (R-HSA-197943)	0.573	2
UniProt:Q14451 GRB7	1	GRB7 [cytosol] (R-HSA-204819)	0.57	3
UniProt:P29350-3 PTPN6			0.57	3
UniProt:Q9NP31 SH2D2A	1	SH2D2A [cytosol] (R-HSA-4420125)	0.57	3
UniProt:Q68CZ2 TNS3	1	TNS3 [cytosol] (R-HSA-8875524)	0.556	3
UniProt:O60711 LPXN			0.547	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.547	2
UniProt:Q62219 TGFI1			0.524	3
UniProt:P16144 ITGB4	1	ITGB4 [plasma membrane] (R-HSA-215947)	0.524	7
UniProt:P08631-2 HCK			0.508	2
UniProt:P29317 EPHA2	2	p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380) EPHA2 [plasma membrane] (R-HSA-2682326)	0.488	3
UniProt:Q8TEW6 DOK4	1	DOK4 [cytosol] (R-HSA-8847701)	0.488	2
UniProt:O60880 SH2D1A	1	SH2D1A [cytosol] (R-HSA-5685108)	0.488	2
UniProt:Q80ZW7 Q80ZW7			0.463	2

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