Autophosphorylation of PTK2 at Y397

Stable Identifier
R-HSA-354073
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The co-localization of PTK2/FAK with integrins in focal adhesions and the actin cytoskeleton is essential for the activation and phosphorylation of PTK2/FAK.
PTK2/FAK has six tyrosine phosphorylation sites and tyrosine 397 is the main auto-phosphorylation site present upstream of the kinase domain.

Literature References
PubMed ID Title Journal Year
16919435 Integrin-regulated FAK-Src signaling in normal and cancer cells

Mitra, SK, Schlaepfer, DD

Curr Opin Cell Biol 2006
11476890 Biochemical signals and biological responses elicited by the focal adhesion kinase

Schaller, MD

Biochim Biophys Acta 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created