Recruitment of GRB2 to p-PTK2

Stable Identifier
R-HSA-354087
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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General
SVG |   | PPTX  | SBGN
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Phosphorylated tyrosine 925 in the FAT domain of PTK2/FAK creates a docking site for the SH2 domain of GRB2 and recruits the GRB2/SOS complex. PTK2 may use this mechanism to activate Ras and the MAP kinase pathway.

Participants
Participant Of
Orthologous Events
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Reviewed
Created