Phosphorylation of pPTK2 by SRC

Stable Identifier
R-HSA-354124
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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The recruitment of FADK1 to active SRC leads to the efficient tyrosine phosphorylation of multiple additional sites on FADK1. SRC trans-phosphorylates FADK1 within the kinase doman activation loop (Y576 and Y577) and within the FADK1 C-terminal domain (Y861 and Y925).

Literature References
PubMed ID Title Journal Year
16919435 Integrin-regulated FAK-Src signaling in normal and cancer cells

Mitra, SK, Schlaepfer, DD

Curr Opin Cell Biol 2006
11476890 Biochemical signals and biological responses elicited by the focal adhesion kinase

Schaller, MD

Biochim Biophys Acta 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created