Activation of Rap1 by cytosolic GEFs

Stable Identifier
R-HSA-354173
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Signals from agonist receptors (such as GPVI) trigger the production of PIP3, DAG, cAMP and elevated Ca++ levels. This leads to the activation and translocation of active Rap1-GTP to the plasma membrane. Rap-GEFs stimulate the replacement of GDP for GTP, activating Rap1. Several Rap1 GEFs have been identified enabling Rap1 to respond to diverse stimuli. CalDAG-GEFs activate Rap1 in response to calcium and DAG, downstream of Phospholipase C. EPAC (exchange proteins directly activated by cAMP) GEFs are activated by binding cAMP.

Literature References
PubMed ID Title Journal Year
16076873 Multiple roles of Rap1 in hematopoietic cells: complementary versus antagonistic functions

Stork, PJ, Dillon, TJ

Blood 2005
16757337 Rap1 regulation of RIAM and cell adhesion

Lafuente, E, Boussiotis, VA

Methods Enzymol 2006
15334074 CalDAG-GEFI integrates signaling for platelet aggregation and thrombus formation

Crittenden, JR, Bergmeier, W, Zhang, Y, Piffath, CL, Liang, Y, Wagner, DD, Housman, DE, Graybiel, AM

Nat Med 2004
15469846 RIAM, an Ena/VASP and Profilin ligand, interacts with Rap1-GTP and mediates Rap1-induced adhesion

Lafuente, EM, van Puijenbroek, AA, Krause, M, Carman, CV, Freeman, GJ, Berezovskaya, A, Constantine, E, Springer, TA, Gertler, FB, Boussiotis, VA

Dev Cell 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
guanyl-nucleotide exchange factor activity of CalDAG-GEFs:DAG:Ca2+ [plasma membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created