Reactome | TNKS [cytosol]

TNKS [cytosol]

Stable Identifier

R-HSA-3640825

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Tankyrase-1, TANK1

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Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
        
        RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
        
        RibC-AXIN:TNKS [cytosol] (Homo sapiens)
        
        TNKS1/2 [cytosol] (Homo sapiens)
        
        TNKS [cytosol] (Homo sapiens)
        
        Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
        
        TNKS1/2 [cytosol] (Homo sapiens)
        
        TNKS [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O95271 TNKS

Gene Names

TNKS, PARP5A, PARPL, TIN1, TINF1, TNKS1

Chain

chain:1-1327

Reference Genes

BioGPS Gene:8658 TNKS

COSMIC (genes):TNKS TNKS

CTD Gene:8658 TNKS

dbSNP Gene:8658 TNKS

ENSEMBL:ENSG00000173273 TNKS

HGNC:11941 TNKS

KEGG:hsa:8658 TNKS

Monarch:8658 TNKS

NCBI Gene:8658 TNKS

OMIM:603303 TNKS

UCSC:O95271 TNKS

Reference Transcript

RefSeq:NM_003747.2 TNKS

Other Identifiers

11718088_at

11718089_at

11745079_a_at

11749640_a_at

1569391_PM_at

1569391_at

17065583

17118319

202561_PM_at

202561_at

216695_PM_s_at

216695_s_at

3085271

3085272

3085273

3085274

3085275

3085278

3085281

3085295

3085296

3085298

3085300

3085304

3085305

3085307

3085308

3085312

3085313

3085314

3085315

3085316

3085317

3085318

3085320

3085321

3085322

3085324

3085327

3085328

3085329

3085332

3085335

3085337

3085338

3085339

3085340

3085344

3085345

3085346

3085347

3085348

3085351

3085352

3085359

3085360

3085361

31473_s_at

31474_r_at

31475_at

31476_g_at

39430_at

8144528

8658

ADDON000993.hg

A_14_P128288

A_14_P128623

A_23_P20927

A_23_P323252

A_32_P144596

GE54727

GE80482

GO:0000139

GO:0000209

GO:0000242

GO:0000781

GO:0000922

GO:0003824

GO:0003950

GO:0005515

GO:0005634

GO:0005643

GO:0005654

GO:0005694

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006355

GO:0007010

GO:0007052

GO:0008270

GO:0015031

GO:0016020

GO:0016055

GO:0016604

GO:0016740

GO:0016757

GO:0016779

GO:0018105

GO:0018107

GO:0031965

GO:0032210

GO:0032212

GO:0042393

GO:0043226

GO:0045944

GO:0046872

GO:0051028

GO:0051225

GO:0051301

GO:0070198

GO:0070212

GO:0070213

GO:0090263

GO:0097431

GO:0140096

GO:1904355

GO:1904357

GO:1904358

GO:1904743

GO:1904908

GO:1990404

HMNXSV003021817

Hs.131814.0.S2_3p_at

Hs.131814.1.S1_3p_a_at

Hs.131814.1.S1_3p_x_at

Hs2.407494.1.S1_3p_at

ILMN_1657891

PH_hs_0019491

TC08000069.hg

Participates

as a member of

TNKS1/2 [cytosol] (Homo sapiens)

Inferred To

Tnks [cytosol] (Rattus norvegicus)

TNKS [cytosol] (Bos taurus)

TNKS [cytosol] (Canis familiaris)

TNKS [cytosol] (Gallus gallus)

TNKS [cytosol] (Mus musculus)

TNKS [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_003738.2

ZINC - World Drugs

TNKS1_HUMAN

Guide to Pharmacology - Targets

3108

OpenTargets

ENSG00000173273

ENSEMBL

ENSP00000311579, ENST00000310430, ENST00000646522, ENSP00000493602

ZINC - FDA approved

TNKS1_HUMAN

ZINC - Substances

TNKS1_HUMAN

ZINC - Biogenic

TNKS1_HUMAN

ZINC target

O95271

PRO

O95271

PDB

3UDD, 4N4V, 5ETY, 4LI8, 5JU5, 4UUH, 4U6A, 3UH2, 4LI7, 5JHQ, 4TOR, 5EBT, 4MT9, 3UH4, 4DVI, 4MSG, 4KRS, 4I9I, 4TOS, 6QXU, 7KKQ, 4N3R, 5ECE, 2RF5, 5GP7, 4K4F, 4W5S, 5JTI, 4K4E, 7OCV, 4LI6, 4W6E, 4OA7, 4MSK, 5KNI, 7KKN, 8X5J, 7KKO, 7KKM, 4UW1, 7KKP, 6URQ

ZINC - Metabolites

TNKS1_HUMAN

HPA

ENSG00000173273-TNKS

Pharos - Targets

O95271

ZINC - Predictions - Purchasable

TNKS1_HUMAN

HMDB Protein

HMDBP00912

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NTX7 RNF146	1	RNF146 [cytosol] (R-HSA-3640827)	0.734	6
UniProt:Q9NWV8 BABAM1	2	BABAM1 [cytosol] (R-HSA-5691418) BABAM1 [nucleoplasm] (R-HSA-5682582)	0.643	4
UniProt:O35625 Axin1	8	Phospho Axin1 [cytosol] (R-MMU-206175) phospho-Axin1 [cytosol] (R-MMU-3640864) phospho-Axin1 [cytosol] (R-MMU-3640841) Axin1 [cytosol] (R-MMU-4641133) Axin1 [cytosol] (R-MMU-205727) Phospho (3 sites) Axin1 [cytosol] (R-MMU-205737) phospho-Axin1 [cytosol] (R-MMU-206040) Axin1 [cytosol] (R-MMU-195249)	0.581	4
UniProt:Q9NX46 ADPRS	1	ADPRHL2 [mitochondrial matrix] (R-HSA-8952910)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [cytosol] (R-HSA-373639) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [extracellular region] (R-HSA-6806206)	0.556	5
UniProt:O60547 GMDS	1	GMDS [cytosol] (R-HSA-6787620)	0.527	2
UniProt:Q07954 LRP1	2	LRP1 [endocytic vesicle membrane] (R-HSA-2230981) LRP1 [plasma membrane] (R-HSA-1454844)	0.527	2
UniProt:Q9HC77 CENPJ	2	CENPJ [cytosol] (R-HSA-380291) p-S589,S595-CENPJ [cytosol] (R-HSA-6801670)	0.463	4