RNF146 binds RibC-AXIN:TNKS complex

Stable Identifier
R-HSA-3640844
Type
Reaction
Species
Homo sapiens
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RNF146 is an E3 RING ubiquitin ligase that was identified as a positive regulator of WNT signalling (Callow et al, 2011; Zhang et al, 2011). Depletion of RNF146 increases the levels of AXIN and decreases expression of WNT target genes and WNT-responsive reporters in a WNT-independent manner (Zhang et al, 2011; Callow et al, 2011). RNF146 binds directly to poly-ADP-ribose groups through its WWE domain and ubiquitinates substrates in a tankyrase-dependent manner (Zhang et al, 2011). AXIN, Tankyrase and RNF146 are thought to exist in a complex (Callow et al, 2011) and RNF146 mediates the tankyrase-dependent ubiquitination of all three proteins to promote their degradation (Callow et al, 2011; Zhang et al, 2011). In this reaction, only the targeted degradation of AXIN is depicted.

Literature References
PubMed ID Title Journal Year
21799911 Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

Callow, MG, Tran, H, Phu, L, Lau, T, Lee, J, Sandoval, WN, Liu, PS, Bheddah, S, Tao, J, Lill, JR, Hongo, JA, Davis, D, Kirkpatrick, DS, Polakis, P, Costa, M

PLoS ONE 2011
21478859 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Zhang, Y, Liu, S, Mickanin, C, Feng, Y, Charlat, O, Michaud, GA, Schirle, M, Shi, X, Hild, M, Bauer, A, Myer, VE, Finan, PM, Porter, JA, Huang, SM, Cong, F

Nat. Cell Biol. 2011
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