Reactome | RNF146 binds RibC-AXIN:TNKS complex

RNF146 binds RibC-AXIN:TNKS complex

Stable Identifier

R-HSA-3640844

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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RNF146 is an E3 RING ubiquitin ligase that was identified as a positive regulator of WNT signalling (Callow et al, 2011; Zhang et al, 2011). Depletion of RNF146 increases the levels of AXIN and decreases expression of WNT target genes and WNT-responsive reporters in a WNT-independent manner (Zhang et al, 2011; Callow et al, 2011). RNF146 binds directly to poly-ADP-ribose groups through its WWE domain and ubiquitinates substrates in a tankyrase-dependent manner (Zhang et al, 2011). AXIN, Tankyrase and RNF146 are thought to exist in a complex (Callow et al, 2011) and RNF146 mediates the tankyrase-dependent ubiquitination of all three proteins to promote their degradation (Callow et al, 2011; Zhang et al, 2011). In this reaction, only the targeted degradation of AXIN is depicted.

Literature References

PubMed ID	Title	Journal	Year
21478859	RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling Mickanin, C, Zhang, Y, Shi, X, Charlat, O, Feng, Y, Cong, F, Schirle, M, Michaud, GA, Hild, M, Porter, JA, Bauer, A, Huang, SM, Myer, VE, Finan, PM, Liu, S	Nat. Cell Biol.	2011
21799911	Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling Kirkpatrick, DS, Bheddah, S, Lau, T, Callow, MG, Lee, J, Davis, D, Sandoval, WN, Polakis, P, Tran, H, Lill, JR, Hongo, JA, Costa, M, Liu, PS, Tao, J, Phu, L	PLoS ONE	2011