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Ub-RibC-AXIN2 [cytosol]
Stable Identifier
R-HSA-3640859
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Deubiquitination (Homo sapiens)
Ub-specific processing proteases (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN [cytosol] (Homo sapiens)
Ub-RibC-AXIN2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Degradation of AXIN (Homo sapiens)
RNF146 ubiquitinates ADP-ribosylated AXIN (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN [cytosol] (Homo sapiens)
Ub-RibC-AXIN2 [cytosol] (Homo sapiens)
Ub-RibC-AXIN is degraded by the proteasome (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN [cytosol] (Homo sapiens)
Ub-RibC-AXIN2 [cytosol] (Homo sapiens)
USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
Ub-RibC-AXIN [cytosol] (Homo sapiens)
Ub-RibC-AXIN2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9Y2T1 AXIN2
Gene Names
AXIN2
Chain
chain:1-843
Reference Genes
BioGPS Gene:8313 AXIN2
COSMIC (genes):AXIN2 AXIN2
CTD Gene:8313 AXIN2
dbSNP Gene:8313 AXIN2
ENSEMBL:ENSG00000168646 AXIN2
HGNC:904 AXIN2
KEGG Gene (Homo sapiens):8313 AXIN2
Monarch:8313 AXIN2
NCBI Gene:8313 AXIN2
OMIM:604025 AXIN2
UCSC:Q9Y2T1 AXIN2
Reference Transcript
RefSeq:NM_004655.3 AXIN2
Other Identifiers
11718451_a_at
11718452_at
11718453_a_at
16847933
222695_PM_s_at
222695_s_at
222696_PM_at
222696_at
224176_PM_s_at
224176_s_at
224498_PM_x_at
224498_x_at
3767466
3767467
3767468
3767477
3767479
3767481
3767483
3767484
3767485
3767486
3767488
3767489
3767490
3767493
3767497
3767528
3767530
59763_s_at
64129_at
8017718
8313
90101_at
A_23_P148015
A_24_P298027
GE58341
GO:0001756
GO:0001934
GO:0001957
GO:0003139
GO:0003413
GO:0003674
GO:0005515
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0006259
GO:0006464
GO:0006950
GO:0007049
GO:0007059
GO:0007165
GO:0007267
GO:0008013
GO:0008150
GO:0008219
GO:0008283
GO:0008285
GO:0009056
GO:0009790
GO:0010718
GO:0010942
GO:0016055
GO:0019899
GO:0019901
GO:0030111
GO:0030154
GO:0030282
GO:0030877
GO:0031625
GO:0032423
GO:0032991
GO:0034613
GO:0034641
GO:0034655
GO:0042476
GO:0043161
GO:0043226
GO:0043570
GO:0045668
GO:0045860
GO:0048255
GO:0048646
GO:0048856
GO:0051276
GO:0061181
GO:0070411
GO:0070602
GO:0071407
GO:0090090
GO:2000054
HMNXSV003007463
Hs.127337.0.S1_3p_a_at
Hs.127337.0.S3_3p_at
ILMN_1724480
TC17002855.hg
g13623398_3p_s_at
g6653583_3p_a_at
Participates
as a member of
Ub-RibC-AXIN [cytosol] (Homo sapiens)
Other forms of this molecule
AXIN2 [cytosol]
RibC-AXIN2 [cytosol]
ub-AXIN2 [cytosol]
Inferred To
phospho-Axin2 [cytosol]
(Mus musculus)
phospho-Axin2 [cytosol]
(Rattus norvegicus)
phospho-AXIN2 [cytosol]
(Bos taurus)
phospho-AXIN2 [cytosol]
(Canis familiaris)
phospho-AXIN2 [cytosol]
(Gallus gallus)
phospho-AXIN2 [cytosol]
(Sus scrofa)
phospho-axin2 [cytosol]
(Danio rerio)
phospho-Axn [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position
PsiMod Name
adenosine diphosphoribosyl (ADP-ribosyl) modified residue
PsiMod Definition
A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_004646.3
OpenTargets
ENSG00000168646
ZINC - Substances
AXIN2_HUMAN
ZINC target
Q9Y2T1
ZINC - Biogenic
AXIN2_HUMAN
PRO
Q9Y2T1
ZINC - Investigational
AXIN2_HUMAN
ZINC - Metabolites
AXIN2_HUMAN
HPA
ENSG00000168646-AXIN2
GeneCards
Q9Y2T1
Ensembl
ENSG00000168646
,
ENST00000307078
,
ENSP00000302625
Pharos - Targets
Q9Y2T1
Orphanet
15346
ZINC - Predictions - Purchasable
AXIN2_HUMAN
Interactors (42)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P49841 GSK3B
4
GSK3B del304-316 [cytosol]
(R-HSA-5339682)
GSK3B [nucleoplasm]
(R-HSA-2022823)
p-S9-GSK3B [cytosol]
(R-HSA-3149577)
GSK3B [cytosol]
(R-HSA-2997551)
0.725
4
UniProt:P62714 PPP2CB
4
MeL-PPP2CB [nucleoplasm]
(R-HSA-8857799)
p-Y307-PPP2CB [cytosol]
(R-HSA-8857935)
PPP2CB [nucleoplasm]
(R-HSA-165991)
PPP2CB [cytosol]
(R-HSA-165987)
0.645
4
UniProt:Q15583 TGIF1
1
TGIF1 [nucleoplasm]
(R-HSA-2186594)
0.567
5
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.564
2
UniProt:Q8NEF3-2 CCDC112
0.556
3
UniProt:Q3B820 F161A
0.556
3
UniProt:Q2TBE0 C19L2
0.556
3
UniProt:Q15560 TCEA2
0.556
3
UniProt:O75558 STX11
0.556
3
UniProt:O95985 TOP3B
0.556
3
UniProt:Q9BYR2 KRTAP4-5
1
KRTAP4-5 [cytosol]
(R-HSA-6809950)
0.556
3
UniProt:O75638-2 CTAG2
0.556
3
UniProt:P49721 PSMB2
2
PSMB2 [nucleoplasm]
(R-HSA-174335)
PSMB2 [cytosol]
(R-HSA-68744)
0.556
3
UniProt:Q9UKJ5 CHIC2
0.556
3
UniProt:Q2NKX9 CB068
0.556
3
UniProt:Q15973 ZNF124
1
ZNF124 [nucleoplasm]
(R-HSA-975017)
0.556
3
UniProt:Q9Y6W3 CAPN7
1
CAPN7 [cytosol]
(R-HSA-8848633)
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q8N3L3 TXLNB
0.556
3
UniProt:P09067 HXB5
0.556
3
UniProt:Q15172 PPP2R5A
1
PPP2R5A [cytosol]
(R-HSA-196235)
0.556
3
UniProt:Q96SQ5 ZNF587
1
ZNF587 [nucleoplasm]
(R-HSA-2127565)
0.556
3
UniProt:Q14241 ELOA
1
TCEB3 [nucleoplasm]
(R-HSA-112421)
0.556
3
UniProt:P60014 KRTAP10-10
1
KRTAP10-10 [cytosol]
(R-HSA-6810293)
0.556
3
UniProt:P60410 KRTAP10-8
1
KRTAP10-8 [cytosol]
(R-HSA-6810301)
0.556
3
UniProt:A2BDD9 A2BDD9
0.556
3
UniProt:Q8TBB1 LNX1
1
LNX1 [cytosol]
(R-HSA-8851641)
0.556
3
UniProt:Q9BZW7 TSG10
0.556
3
UniProt:Q9BXS5 AP1M1
7
AP1M1 [cytoplasmic vesicle membrane]
(R-HSA-351196)
AP1M1 [Golgi membrane]
(R-HSA-350805)
AP1M1 [lysosomal membrane]
(R-HSA-432708)
AP1M1 [trans-Golgi network membrane]
(R-HSA-2130512)
AP1M1 [cytosol]
(R-HSA-167700)
AP1M1 [plasma membrane]
(R-HSA-6806311)
AP1M1 [specific granule membrane]
(R-HSA-6799365)
0.556
3
UniProt:Q5T619 ZN648
0.556
3
UniProt:Q9BVG8-5 KIFC3
0.556
3
UniProt:Q96EZ8 MCRS1
1
MCRS1 [nucleoplasm]
(R-HSA-3321849)
0.556
3
UniProt:Q13895 BYSL
2
BYSL [nucleoplasm]
(R-HSA-6791526)
BYSL [cytosol]
(R-HSA-6791518)
0.556
3
UniProt:P40222 TXLNA
1
TXLNA [cytosol]
(R-HSA-449124)
0.556
3
UniProt:Q99728 BARD1
13
BARD1 G623E [nucleoplasm]
(R-HSA-9699135)
BARD1 C71Y [nucleoplasm]
(R-HSA-9700808)
BARD1 C53W [nucleoplasm]
(R-HSA-9700807)
BARD1 G623W [nucleoplasm]
(R-HSA-9699148)
BARD1 W34R [nucleoplasm]
(R-HSA-9699166)
BARD1 H68Y [nucleoplasm]
(R-HSA-9699151)
BARD1 L44R [nucleoplasm]
(R-HSA-9699126)
BARD1 C50G [nucleoplasm]
(R-HSA-9699137)
BARD1 C83G [nucleoplasm]
(R-HSA-9699139)
K6PolyUb,p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-9707286)
p-T714,T734-BARD1 [nucleoplasm]
(R-HSA-5659846)
K6PolyUb-BARD1 [nucleoplasm]
(R-HSA-9701024)
BARD1 [nucleoplasm]
(R-HSA-5659775)
0.556
3
UniProt:Q9Y297 BTRC
2
BTRC [cytosol]
(R-HSA-174237)
BTRC [nucleoplasm]
(R-HSA-3361753)
0.556
3
UniProt:Q9BWG6 SCNM1
0.556
3
UniProt:Q8TAU3 ZNF417
1
ZNF417 [nucleoplasm]
(R-HSA-1247539)
0.556
3
UniProt:Q9BYQ4 KRTAP9-2
1
KRTAP9-2 [cytosol]
(R-HSA-6809965)
0.556
3
UniProt:P49840 GSK3A
3
GSK3A [cytosol]
(R-HSA-198326)
p-S21-GSK3A [cytosol]
(R-HSA-198352)
p-Y279-GSK3A [cytosol]
(R-HSA-9635490)
0.547
2
UniProt:Q8N944 AMER3
0.499
2
UniProt:Q9Y4X0 AMMR1
0.463
2
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