Reactome | Ub-RibC-AXIN2 [cytosol]

Ub-RibC-AXIN2 [cytosol]

Stable Identifier

R-HSA-3640859

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Deubiquitination (Homo sapiens)
    - Ub-specific processing proteases (Homo sapiens)
      - USP34 deubiquitinates AXIN1,AXIN2 (Homo sapiens)
        
        Ub-RibC-AXIN:TNKS:RNF146 [cytosol] (Homo sapiens)
        
        Ub-RibC-AXIN [cytosol] (Homo sapiens)
        
        Ub-RibC-AXIN2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9Y2T1 AXIN2

Gene Names

AXIN2

Chain

chain:1-843

Reference Genes

BioGPS Gene:8313 AXIN2

COSMIC (genes):AXIN2 AXIN2

CTD Gene:8313 AXIN2

dbSNP Gene:8313 AXIN2

ENSEMBL:ENSG00000168646 AXIN2

HGNC:904 AXIN2

KEGG Gene (Homo sapiens):8313 AXIN2

Monarch:8313 AXIN2

NCBI Gene:8313 AXIN2

OMIM:604025 AXIN2

UCSC:Q9Y2T1 AXIN2

Reference Transcript

RefSeq:NM_004655.3 AXIN2

Other Identifiers

11718451_a_at

11718452_at

11718453_a_at

12283

16847933

17783

222695_s_at

222696_at

224176_s_at

224498_x_at

3767466

3767467

3767468

3767477

3767479

3767481

3767483

3767484

3767485

3767486

3767488

3767489

3767490

3767493

3767497

3767528

3767530

59763_s_at

64129_at

8017718

8313

90101_at

A0A087WXP8

A0A1B0GX50

A_23_P148015

A_24_P298027

AXIN2

AXIN2-201

CAB012283

CAB017783

CCDS11662

E7ES00

ENSG00000168646

ENSP00000302625

ENST00000307078

ENST00000307078.9

EntrezGene:8313

EntrezGene:AXIN2

F5GX43

g13623398_3p_s_at

g6653583_3p_a_at

GE58341

GO:0001756

GO:0001934

GO:0001957

GO:0003139

GO:0003413

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0006259

GO:0006464

GO:0006950

GO:0007049

GO:0007059

GO:0007165

GO:0007267

GO:0007275

GO:0008013

GO:0008150

GO:0008219

GO:0008283

GO:0008285

GO:0009056

GO:0009790

GO:0010718

GO:0010942

GO:0016055

GO:0019899

GO:0022607

GO:0030111

GO:0030154

GO:0030282

GO:0030877

GO:0031625

GO:0032423

GO:0032991

GO:0034613

GO:0034641

GO:0034655

GO:0042476

GO:0043226

GO:0043570

GO:0045668

GO:0048255

GO:0048646

GO:0048856

GO:0051276

GO:0061181

GO:0065003

GO:0070411

GO:0070602

GO:0090090

GO:0090263

GO:1904837

HGNC:904

Hs.127337.0.S1_3p_a_at

Hs.127337.0.S3_3p_at

ILMN_1724480

IPR001158

IPR014936

IPR016137

IPR024066

IPR029071

IPR032101

IPR036305

IPR038207

J3QQJ3

J3QRK4

LRG_296

MIM:114500

MIM:604025

MIM:608615

NM_004655

NP_004646

PF00615

PF00778

PF08833

PF16646

PR01301

SM00021

SM00315

TC17002855.hg

UPI00001AEE5A

XM_011525319

XM_011525320

XM_011525321

XM_017025192

XP_011523621

XP_011523622

XP_011523623

XP_016880681

Participant Of

hasMember

Ub-RibC-AXIN [cytosol]

Other forms of this molecule

AXIN2 [cytosol]

RibC-AXIN2 [cytosol]

ub-AXIN2 [cytosol]

Inferred To

phospho-Axin2 [cytosol] (Mus musculus)

phospho-Axin2 [cytosol] (Rattus norvegicus)

phospho-AXIN2 [cytosol] (Bos taurus)

phospho-AXIN2 [cytosol] (Canis familiaris)

phospho-AXIN2 [cytosol] (Gallus gallus)

phospho-Ub-RibC-AXIN2 [cytosol] (Sus scrofa)

phospho-slc38a3 [cytosol] (Xenopus tropicalis)

phospho-axin2 [cytosol] (Danio rerio)

phospho-Axn [cytosol] (Drosophila melanogaster)

Modified Residues

Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue at unknown position

PsiMod Name

adenosine diphosphoribosyl (ADP-ribosyl) modified residue

PsiMod Definition

A protein modification that effectively results from forming an adduct with ADP-ribose through formation of a glycosidic bond.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at unknown position

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_004646.3

OpenTargets

ENSG00000168646

GeneCards

Q9Y2T1

ZINC - Substances

AXIN2_HUMAN

HPA

ENSG00000168646-AXIN2

Ensembl

ENST00000307078, ENSG00000168646, ENSP00000302625

ZINC target

Q9Y2T1

PRO

Q9Y2T1

ZINC - Predictions - Purchasable

AXIN2_HUMAN

Orphanet

15346

Interactors (41)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62714 PPP2CB	4	MeL-PPP2CB [nucleoplasm] (R-HSA-8857799) p-Y307-PPP2CB [cytosol] (R-HSA-8857935) PPP2CB [nucleoplasm] (R-HSA-165991) PPP2CB [cytosol] (R-HSA-165987)	0.645	4
UniProt:P49841 GSK3B	4	p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.643	3
UniProt:Q15583 TGIF1	1	TGIF1 [nucleoplasm] (R-HSA-2186594)	0.567	5
UniProt:P35222 CTNNB1	33	CTNNB1 S45F [cytosol] (R-HSA-4791268) CTNNB1 S45A [cytosol] (R-HSA-9663982) CTNNB1 S45C [cytosol] (R-HSA-9663983) CTNNB1 S45Y [cytosol] (R-HSA-9663975) CTNNB1 S45N [cytosol] (R-HSA-9663984) CTNNB1 S45P [cytosol] (R-HSA-4791272) pT41,S45-CTNNB1 S37P [cytosol] (R-HSA-9663981) pT41,S45-CTNNB1 S37F [cytosol] (R-HSA-4839621) pT41,S45-CTNNB1 S37A [cytosol] (R-HSA-4839619) pT41,S45-CTNNB1 S37Y [cytosol] (R-HSA-9663978) pT41,S45-CTNNB1 S37C [cytosol] (R-HSA-4839617) pS37,T41,S45-CTNNB1 S33A [cytosol] (R-HSA-9663976) pS37,T41,S45-CTNNB1 S33T [cytosol] (R-HSA-9663977) pS37,T41,S45-CTNNB1 S33C [cytosol] (R-HSA-4839630) pS37,T41,S45-CTNNB1 S33F [cytosol] (R-HSA-4839628) pS37,T41,S45-CTNNB1 S33P [cytosol] (R-HSA-4839626) pS37,T41,S45-CTNNB1 S33Y [cytosol] (R-HSA-4839625) pS45-CTNNB1 T41N [cytosol] (R-HSA-9663980) pS45-CTNNB1 T41A [cytosol] (R-HSA-4836868) pS45-CTNNB1 T41I [cytosol] (R-HSA-4839612) Ub-K,p-Y-CTNNB1 [cytosol] (R-HSA-8877006) p-Y-CTNNB1 [cytosol] (R-HSA-8876940) p-S552-CTNNB1 [cytosol] (R-HSA-3134933) p-S552-CTNNB1 [nucleoplasm] (R-HSA-3134926) CTNNB1(116-376) [cytosol] (R-HSA-202950) CTNNB1(1-115) [cytosol] (R-HSA-202930) CTNNB1 [plasma membrane] (R-HSA-9038440) p-S45 CTNNB1 [cytosol] (R-HSA-8942363) p-T41,S45 CTNNB1 [cytosol] (R-HSA-8942367) p-S37,T41,S45, CTNNB1 [cytosol] (R-HSA-8942369) p-S33,S37,T41,S45 CTNNB1 [cytosol] (R-HSA-8942374) CTNNB1 [cytosol] (R-HSA-448839) CTNNB1 [nucleoplasm] (R-HSA-3451168)	0.564	2
UniProt:Q8NEF3-2 CCDC112			0.556	3
UniProt:Q3B820 F161A			0.556	3
UniProt:Q2TBE0 C19L2			0.556	3
UniProt:Q15560 TCEA2			0.556	3
UniProt:O75558 STX11			0.556	3
UniProt:O95985 TOP3B			0.556	3
UniProt:Q9BYR2 KRTAP4-5	1	KRTAP4-5 [cytosol] (R-HSA-6809950)	0.556	3
UniProt:O75638-2 CTAG2			0.556	3
UniProt:P49721 PSMB2	2	PSMB2 [cytosol] (R-HSA-68744) PSMB2 [nucleoplasm] (R-HSA-174335)	0.556	3
UniProt:Q9UKJ5 CHIC2			0.556	3
UniProt:Q2NKX9 CB068			0.556	3
UniProt:Q15973 ZNF124	1	ZNF124 [nucleoplasm] (R-HSA-975017)	0.556	3
UniProt:Q9Y6W3 CAPN7	1	CAPN7 [cytosol] (R-HSA-8848633)	0.556	3
UniProt:Q8N8B7-2 TCEANC			0.556	3
UniProt:Q13895 BYSL	2	BYSL [cytosol] (R-HSA-6791518) BYSL [nucleoplasm] (R-HSA-6791526)	0.556	3
UniProt:Q8N3L3 TXLNB			0.556	3
UniProt:Q99728 BARD1	2	BARD1 [nucleoplasm] (R-HSA-5659775) p-T714,T734-BARD1 [nucleoplasm] (R-HSA-5659846)	0.556	3
UniProt:P09067 HXB5			0.556	3
UniProt:Q15172 PPP2R5A	1	PPP2R5A [cytosol] (R-HSA-196235)	0.556	3
UniProt:Q96SQ5 ZNF587	1	ZNF587 [nucleoplasm] (R-HSA-2127565)	0.556	3
UniProt:Q14241 ELOA	1	TCEB3 [nucleoplasm] (R-HSA-112421)	0.556	3
UniProt:P60014 KRTAP10-10	1	KRTAP10-10 [cytosol] (R-HSA-6810293)	0.556	3
UniProt:P60410 KRTAP10-8	1	KRTAP10-8 [cytosol] (R-HSA-6810301)	0.556	3
UniProt:Q9Y297 BTRC	2	BTRC [nucleoplasm] (R-HSA-3361753) BTRC [cytosol] (R-HSA-174237)	0.556	3
UniProt:Q9BWG6 SCNM1			0.556	3
UniProt:Q8TAU3 ZNF417	1	ZNF417 [nucleoplasm] (R-HSA-1247539)	0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:Q96EZ8 MCRS1	1	MCRS1 [nucleoplasm] (R-HSA-3321849)	0.556	3
UniProt:Q9BVG8-5 KIFC3			0.556	3
UniProt:Q5T619 ZN648			0.556	3
UniProt:Q9BXS5 AP1M1	7	AP1M1 [Golgi membrane] (R-HSA-350805) AP1M1 [cytoplasmic vesicle membrane] (R-HSA-351196) AP1M1 [lysosomal membrane] (R-HSA-432708) AP1M1 [trans-Golgi network membrane] (R-HSA-2130512) AP1M1 [cytosol] (R-HSA-167700) AP1M1 [plasma membrane] (R-HSA-6806311) AP1M1 [specific granule membrane] (R-HSA-6799365)	0.556	3
UniProt:Q9BZW7 TSG10			0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:A2BDD9 A2BDD9			0.556	3
UniProt:P40222 TXLNA	1	TXLNA [cytosol] (R-HSA-449124)	0.556	3
UniProt:Q8N944 AMER3			0.499	2
UniProt:Q9Y4X0 AMMR1			0.463	2

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