RNF146 ubiquitinates ADP-ribosylated AXIN

Stable Identifier
R-HSA-3640861
Type
Reaction
Species
Homo sapiens
Compartment
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RNF146 has in vitro and in vivo ubiquitination activity against AXIN, Tankyrase and itself (Callow et al, 2011; Zhang et al, 2011).

Literature References
PubMed ID Title Journal Year
21799911 Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

Callow, MG, Tran, H, Phu, L, Lau, T, Lee, J, Sandoval, WN, Liu, PS, Bheddah, S, Tao, J, Lill, JR, Hongo, JA, Davis, D, Kirkpatrick, DS, Polakis, P, Costa, M

PLoS ONE 2011
21478859 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Zhang, Y, Liu, S, Mickanin, C, Feng, Y, Charlat, O, Michaud, GA, Schirle, M, Shi, X, Hild, M, Bauer, A, Myer, VE, Finan, PM, Porter, JA, Huang, SM, Cong, F

Nat. Cell Biol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin protein ligase activity of RibC-AXIN:TNKS:RNF146 [cytosol]
Physical Entity
Activity
Orthologous Events
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