USP34 deubiquitinates AXIN1,AXIN2

Stable Identifier
R-HSA-3640872
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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UBP34 (also known as USP34) is a ubiquitin protease that co-precipitates in AXIN-containing complexes. In vitro studies show that the core domain of UBP34 is able to deubiquitinate AXIN purified from HEK293 transfected cells, and knockdown of UBP34 reduces AXIN1 protein levels in vivo. Treatment of UBP34-knockdown cells with the tankyrase inhibitor XAV939 reverses the degradation of AXIN, suggesting that the activity of UBP34 counteracts the tankyrase-dependent ubiquitination and degradation of AXIN. UBP34 plays a not-fully characterized role in the nuclear accumulation of AXIN, where AXIN is thought to positively regulate beta-catenin mediated transcription (Lui et al, 2011).

Literature References
PubMed ID Title Journal Year
21383061 The ubiquitin-specific protease USP34 regulates axin stability and Wnt/?-catenin signaling

Lui, TT, Lacroix, C, Ahmed, SM, Goldenberg, SJ, Leach, CA, Daulat, AM, Angers, S

Mol. Cell. Biol. 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thiol-dependent ubiquitinyl hydrolase activity of USP34 [cytosol]
Physical Entity
Activity
Orthologous Events
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Created