Ub-RibC-AXIN is degraded by the proteasome

Stable Identifier
R-HSA-3640874
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
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In the presence of the proteasome inhibitor MG132, polyubiquitinated forms of AXIN accumulate (Huang et al, 2009; Zhang et al, 2011; Callow et al, 2011). This effect is abrogated by co-treatment of cells with both MG132 and inhibitors of tankyrase activity, suggesting that both PARSylation and ubiquitination are required for AXIN degradation (Huang et al, 2009).

Literature References
PubMed ID Title Journal Year
19759537 Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Huang, SM, Mishina, YM, Liu, S, Cheung, A, Stegmeier, F, Michaud, GA, Charlat, O, Wiellette, E, Zhang, Y, Wiessner, S, Hild, M, Shi, X, Wilson, CJ, Mickanin, C, Myer, V, Fazal, A, Tomlinson, R, Serluca, F, Shao, W, Cheng, H, Shultz, M, Rau, C, Schirle, M, Schlegl, J, Ghidelli, S, Fawell, S, Lu, C, Curtis, D, Kirschner, MW, Lengauer, C, Finan, PM, Tallarico, JA, Bouwmeester, T, Porter, JA, Bauer, A, Cong, F

Nature 2009
21478859 RNF146 is a poly(ADP-ribose)-directed E3 ligase that regulates axin degradation and Wnt signalling

Zhang, Y, Liu, S, Mickanin, C, Feng, Y, Charlat, O, Michaud, GA, Schirle, M, Shi, X, Hild, M, Bauer, A, Myer, VE, Finan, PM, Porter, JA, Huang, SM, Cong, F

Nat. Cell Biol. 2011
21799911 Ubiquitin ligase RNF146 regulates tankyrase and Axin to promote Wnt signaling

Callow, MG, Tran, H, Phu, L, Lau, T, Lee, J, Sandoval, WN, Liu, PS, Bheddah, S, Tao, J, Lill, JR, Hongo, JA, Davis, D, Kirkpatrick, DS, Polakis, P, Costa, M

PLoS ONE 2011
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
endopeptidase activity of 26S proteasome [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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