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SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+

Stable Identifier
R-HSA-3697860
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Copper chaperone of superoxide dismutase (CCS) transfers a copper(I) atom to a SOD1 monomer that already contains a Zn atom (Culotta et al. 1997, Casareno et al. 1998, Rae et al. 2001, Brown et al. 2004, Banci et al. 2012). The reaction proceeds by a two step mechanism in which SOD1 first forms heterodimers with CCS (Rae et al. 2001, Banci et al. 2012).

Participants
Participant Of
Orthologous Events