PRDX5 reduces peroxynitrite to nitrite using TXN

Stable Identifier
R-HSA-3697882
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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PRDX5 reduces peroxynitrite to nitrite using TXN
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Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using thioredoxin to yield nitrite (NO2-), water, and oxidized thioredoxin (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.
Literature References
PubMed ID Title Journal Year
15280035 Human peroxiredoxin 5 is a peroxynitrite reductase

Nauser, T, Vander Stricht, D, Etienne, F, Rees, JF, Dubuisson, M, Knoops, B, Koppenol, WH, Clippe, A, Kissner, R

FEBS Lett. 2004
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Catalyst Activity

thioredoxin peroxidase activity of PRDX5 [cytosol]

Physical Entity
PRDX5 [cytosol] (Homo sapiens)
Activity
thioredoxin peroxidase activity (GO:0008379)
Orthologous Events
PRDX5 reduces peroxynitrite to nitrite using TXN (Bos taurus)
PRDX5 reduces peroxynitrite to nitrite using TXN (Canis familiaris)
PRDX5 reduces peroxynitrite to nitrite using TXN (Danio rerio)
PRDX5 reduces peroxynitrite to nitrite using TXN (Dictyostelium discoideum)
PRDX5 reduces peroxynitrite to nitrite using TXN (Drosophila melanogaster)
PRDX5 reduces peroxynitrite to nitrite using TXN (Mus musculus)
PRDX5 reduces peroxynitrite to nitrite using TXN (Plasmodium falciparum)
PRDX5 reduces peroxynitrite to nitrite using TXN (Rattus norvegicus)
PRDX5 reduces peroxynitrite to nitrite using TXN (Saccharomyces cerevisiae)
PRDX5 reduces peroxynitrite to nitrite using TXN (Schizosaccharomyces pombe)
PRDX5 reduces peroxynitrite to nitrite using TXN (Sus scrofa)
Authored
May, B  (2013-06-09)
Reviewed
Kavdia, M  (2013-11-01)
Created
May, B  (2013-06-09)
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