PRDX5 reduces peroxynitrite to nitrite using TXN

Stable Identifier
R-HSA-3697882
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using thioredoxin to yield nitrite (NO2-), water, and oxidized thioredoxin (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.

Literature References
PubMed ID Title Journal Year
15280035 Human peroxiredoxin 5 is a peroxynitrite reductase

Dubuisson, M, Vander Stricht, D, Clippe, A, Etienne, F, Nauser, T, Kissner, R, Koppenol, WH, Rees, JF, Knoops, B

FEBS Lett. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin peroxidase activity of PRDX5 [cytosol]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created