PRDX5 reduces peroxynitrite to nitrite using TXN2

Stable Identifier
R-HSA-3697894
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using TXN2 in mitochodria to yield nitrite (NO2-), water, and oxidized TXN2 (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.
Literature References
PubMed ID Title Journal Year
15280035 Human peroxiredoxin 5 is a peroxynitrite reductase

Nauser, T, Vander Stricht, D, Etienne, F, Rees, JF, Dubuisson, M, Knoops, B, Koppenol, WH, Clippe, A, Kissner, R

FEBS Lett. 2004
12446202 Peroxynitrite reactions and formation in mitochondria

Hodara, R, Cassina, A, Radi, R, Castro, L, Quijano, C

Free Radic. Biol. Med. 2002
Participants
Participates
Catalyst Activity

thioredoxin peroxidase activity of PRDX5-1 [mitochondrial matrix]

Orthologous Events
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