PRDX5 reduces peroxynitrite to nitrite using TXN2

Stable Identifier
R-HSA-3697894
Type
Reaction
Species
Homo sapiens
Compartment
mitochondrial matrix
Locations in the PathwayBrowser
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Summation

Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using TXN2 in mitochodria to yield nitrite (NO2-), water, and oxidized TXN2 (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.

Literature References
PubMed ID Title Journal Year
12446202 Peroxynitrite reactions and formation in mitochondria

Radi, R, Cassina, A, Hodara, R, Quijano, C, Castro, L

Free Radic. Biol. Med. 2002
15280035 Human peroxiredoxin 5 is a peroxynitrite reductase

Dubuisson, M, Vander Stricht, D, Clippe, A, Etienne, F, Nauser, T, Kissner, R, Koppenol, WH, Rees, JF, Knoops, B

FEBS Lett. 2004
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
thioredoxin peroxidase activity of PRDX5-1 [mitochondrial matrix]
Physical Entity
PRDX5-1 [mitochondrial matrix]
Activity
thioredoxin peroxidase activity (0008379)
Orthologous Events
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Bos taurus)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Danio rerio)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Dictyostelium discoideum)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Drosophila melanogaster)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Mus musculus)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Rattus norvegicus)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Sus scrofa)
PRDX5 reduces peroxynitrite to nitrite using TXN2 (Xenopus tropicalis)
Authored
May, B  (2013-06-09)
Reviewed
Kavdia, M  (2013-11-01)