PRDX5 reduces peroxynitrite to nitrite using TXN2

Stable Identifier
R-HSA-3697894
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Peroxiredoxin 5 (PRDX5) very efficiently reduces peroxynitrite using TXN2 in mitochodria to yield nitrite (NO2-), water, and oxidized TXN2 (Dubuisson et al. 2004). The N-terminal cysteine (Cys 47) of PRDX5 attacks the O-O peroxide bond of peroxynitrite.

Literature References
PubMed ID Title Journal Year
12446202 Peroxynitrite reactions and formation in mitochondria

Radi, R, Cassina, A, Hodara, R, Quijano, C, Castro, L

Free Radic. Biol. Med. 2002
15280035 Human peroxiredoxin 5 is a peroxynitrite reductase

Dubuisson, M, Vander Stricht, D, Clippe, A, Etienne, F, Nauser, T, Kissner, R, Koppenol, WH, Rees, JF, Knoops, B

FEBS Lett. 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
thioredoxin peroxidase activity of PRDX5-1 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed