Reactome: A Curated Pathway Database

Transcriptional Regulation by TP53

Stable Identifier
R-HSA-3700989
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
Summation

The tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many genes involved in a variety of cellular processes, such as cellular metabolism, survival, senescence, apoptosis and DNA damage response. Because of its critical function, p53 is frequently mutated in around 50% of all malignant tumors. For a recent review, please refer to Vousden and Prives 2009 and Kruiswijk et al. 2015.

Literature References
PubMed ID Title Journal Year
Participants
Participant Of
Orthologous Events