Transcriptional Regulation by TP53

Stable Identifier
R-HSA-3700989
Type
Pathway
Species
Homo sapiens
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General
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The tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many genes involved in a variety of cellular processes, such as cellular metabolism, survival, senescence, apoptosis and DNA damage response. Because of its critical function, p53 is frequently mutated in around 50% of all malignant tumors. For a recent review, please refer to Vousden and Prives 2009 and Kruiswijk et al. 2015.

Literature References
PubMed ID Title Journal Year
19410540 Blinded by the Light: The Growing Complexity of p53

Vousden, KH, Prives, C

Cell 2009
26122615 p53 in survival, death and metabolic health: a lifeguard with a licence to kill

Kruiswijk, F, Labuschagne, CF, Vousden, KH

Nat. Rev. Mol. Cell Biol. 2015
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