TP53 stimulates MDM2 transcription

Stable Identifier
R-HSA-3700992
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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TP53 stimulates MDM2 transcription
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Binding of TP53 (p53) to the p53 response element in the first intron of the MDM2 gene stimulates MDM2 transcription (Wu et al. 1993).
Literature References
PubMed ID Title Journal Year
8319905 The p53-mdm-2 autoregulatory feedback loop

Levine, AJ, Olson, D, Bayle, JH, Wu, X

Genes Dev. 1993
Participants
Input
Output
Participates
as an event of
This event is regulated
Positively by
Regulator
p-S15,S20-TP53 Tetramer:MDM2 Gene [nucleoplasm] (Homo sapiens)
Active Unit
p-S15,S20-TP53 Tetramer [nucleoplasm]
Authored
Orlic-Milacic, M  (2015-10-14)
Reviewed
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Created
Orlic-Milacic, M  (2013-06-11)
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