An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 MH2 domain mutants

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

As SMAD2 and SMAD3 MH2 domain mutations mainly affect amino acid residues involved in SMAD oligomerization (Fleming et al. 2013) and not residues involved in SMAD2/SMAD3 binding to ZFYVE9 (SARA) (Wu et al. 2000), it is assumed that SARA can recruit SMAD2/3 MH2 domain mutants to activated TGF-beta receptor 1 (TGFBR1), but this has not been experimentally examined.

Literature References
PubMed ID Title Journal Year
23139211 SMAD2, SMAD3 and SMAD4 mutations in colorectal cancer

Fleming, NI, Jorissen, RN, Mouradov, D, Christie, M, Sakthianandeswaren, A, Palmieri, M, Day, F, Li, S, Tsui, C, Lipton, L, Desai, J, Jones, IT, McLaughlin, S, Ward, RL, Hawkins, NJ, Ruszkiewicz, AR, Moore, J, Zhu, HJ, Mariadason, JM, Burgess, AW, Busam, D, Zhao, Q, Strausberg, RL, Gibbs, P, Sieber, OM

Cancer Res. 2013
10615055 Structural basis of Smad2 recognition by the Smad anchor for receptor activation

Wu, G, Chen, YG, Ozdamar, B, Gyuricza, CA, Chong, PA, Wrana, JL, Massagué, J, Shi, Y

Science 2000
Participant Of
Catalyst Activity
Catalyst Activity
protein binding activity of ZFYVE9-1 [early endosome membrane]
Physical Entity
Normal reaction
Name Identifier Synonyms
cancer 162 malignant tumor, malignant neoplasm, primary cancer