Reactome: A Curated Pathway Database

phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]

Stable Identifier
R-HSA-372449
Type
Reaction
Species
Homo sapiens
Compartment
Synonyms
Exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate
Locations in the PathwayBrowser
Summation

SLC25A1, in the inner mitochondrial membrane, mediates the exchange of cytosolic citrate for mitochondrial phosphoenolpyruvate. The exchange is physiologically irreversible because of the potential of the inner mitochondrial membrane. The gene encoding human SLC25A1 has been cloned and its expression pattern has been characterized (Heisterkamp et al. 1995; Iacobazzi et al. 1997), but the biochemical details of the transport process are inferred from those worked out for the well-characterized rat system (Robinson 1971; Soling et al. 1971; Kleineke et al. 1973).

Literature References
Participants
Participant Of
hasEvent
This entity is regulated by:
Title Physical Entity Activity
tricarboxylic acid transmembrane transporter activity of SLC25A1 [mitochondrial inner membrane] SLC25A1 [mitochondrial inner membrane] tricarboxylic acid transmembrane transporter activity (0015142)
Orthologous Events