2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]

Stable Identifier
R-HSA-372480
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Synonyms
Exchange of cytosolic 2-oxoadipate for mitochondrial 2-oxoglutarate
Locations in the PathwayBrowser
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SLC25A21, the mitochondrial 2-oxodicarboxylate carrier, mediates the exchange of 2-oxoadipate and 2-oxoglutarate across the inner mitochondrial membrane. While the exchange is reversible, under physiological conditions it proceeds in the direction of 2-oxoadipate import into the mitochondrial matrix and 2-oxoglutarate export (Fiermonte et al. 2001).

Literature References
PubMed ID Title Journal Year
11083877 Identification of the human mitochondrial oxodicarboxylate carrier. Bacterial expression, reconstitution, functional characterization, tissue distribution, and chromosomal location

Fiermonte, G, Dolce, V, Palmieri, L, Ventura, M, Runswick, MJ, Palmieri, F, Walker, JE

J Biol Chem 2001
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
alpha-ketoglutarate transmembrane transporter activity of SLC25A21 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Created