Reactome | DOCK1 [cytosol]

DOCK1 [cytosol]

Stable Identifier

R-HSA-372654

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

DOCK180

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - Netrin-1 signaling (Homo sapiens)
      - DCC mediated attractive signaling (Homo sapiens)
        
        Activation of Cdc42 (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        Activation of Rac1 (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        Recruitment and activation of N-WASP by Cdc42 (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP:WASL:PIP2 [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:CDC42:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        Recruitment of ABLIM to the plasma membrane (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP:ABLIM [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO:RAC1:GTP [plasma membrane] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        RhoGTPase GEF's recruited to DCC (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)
        
        NTN1:p-Y1420-DCC oligomer:p-Y397-PTK2:MyrG-p-Y419-SRC,MyrG-p-Y420-FYN:NCK1:DOCK1,TRIO [plasma membrane] (Homo sapiens)
        
        DOCK1,TRIO [cytosol] (Homo sapiens)
        
        DOCK1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q14185 DOCK1

Gene Names

DOCK1

Chain

chain:1-1865

Reference Genes

BioGPS Gene:1793 DOCK1

COSMIC (genes):DOCK1 DOCK1

CTD Gene:1793 DOCK1

dbSNP Gene:1793 DOCK1

ENSEMBL:ENSG00000150760 DOCK1

HGNC:2987 DOCK1

KEGG:hsa:1793 DOCK1

Monarch:1793 DOCK1

NCBI Gene:1793 DOCK1

OMIM:601403 DOCK1

UCSC:Q14185 DOCK1

Reference Transcript

RefSeq:NM_001380.4 DOCK1

Other Identifiers

11740909_s_at

11754336_s_at

16710481

1793

203187_PM_at

203187_at

241708_PM_at

241708_at

241709_PM_s_at

241709_s_at

3269941

3269942

3269943

3269956

3269960

3269964

3269966

3269967

3269968

3269970

3269971

3269974

3269976

3269977

3269979

3269980

3269984

3269985

3269986

3269991

3269993

3269996

3269997

3269998

3269999

3270000

3270018

3270019

3270024

3270025

3270026

3270048

3270050

3270051

3270058

3270070

3270071

3270073

3270074

3270077

3270078

3270079

3270080

3270086

3270087

3270089

3270090

3270091

3270099

3270100

3270106

3270107

3270109

3270114

3270118

3270119

3270120

3270123

3270124

3270125

3270127

3270128

3270132

3270133

3270138

3270139

3270140

37638_at

7931293

87247_at

D50857_at

GE57249

GO:0002244

GO:0005085

GO:0005096

GO:0005515

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006909

GO:0006911

GO:0006915

GO:0007165

GO:0007229

GO:0007264

GO:0007520

GO:0010634

GO:0012501

GO:0016020

GO:0016192

GO:0016477

GO:0016607

GO:0017124

GO:0030154

GO:0031267

GO:0032045

GO:0048870

GO:0061024

GO:0098772

GO:0098794

GO:0098978

GO:0150052

GO:1900026

HMNXSV003016325

Hs.309770.0.A1_3p_at

Hs.309770.0.A1_3p_s_at

ILMN_1715789

PH_hs_0033414

TC10000918.hg

g4503354_3p_at

p33755

Participates

as a candidate of

as a member of

as a component of

Inferred To

docD [cytosol] (Dictyostelium discoideum)

DOCK1 [cytosol] (Bos taurus)

DOCK1 [cytosol] (Canis familiaris)

DOCK1 [cytosol] (Gallus gallus)

DOCK1 [cytosol] (Sus scrofa)

Dock1 [cytosol] (Mus musculus)

dock1 [cytosol] (Danio rerio)

dock1 [cytosol] (Xenopus tropicalis)

ced-5 [cytosol] (Caenorhabditis elegans)

DCK1 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of DOCK1 [cytosol] (Rattus norvegicus)

mbc [cytosol] (Drosophila melanogaster)

Cross References

RefSeq

NP_001371.1

ENSEMBL

ENST00000280333, ENSP00000280333

OpenTargets

ENSG00000150760

HPA

ENSG00000150760-DOCK1

PRO

Q14185

Pharos - Targets

Q14185

GlyGen

Q14185

HMDB Protein

HMDBP08352

PDB

3L4C

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q92556 ELMO1	1	ELMO1 [cytosol] (R-HSA-200932)	0.937	20
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.809	6
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.77	5
UniProt:P63000 RAC1	6	RAC1 [plasma membrane] (R-HSA-351141) RAC1 [cytosol] (R-HSA-442615) GGC-PalmC-RAC1 [plasma membrane] (R-HSA-2316446) RAC1 [ficolin-1-rich granule membrane] (R-HSA-6804802) RAC1 [secretory granule membrane] (R-HSA-6804770) RAC1 [endoplasmic reticulum membrane] (R-HSA-5672076)	0.734	10
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.593	3
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.527	2

Cite Us!