Recruitment of BCAR1 to PTK2 complex

Stable Identifier
R-HSA-372705
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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BCAR1 (breast cancer anti-estrogen resistance protein1, also known as Crk-associated substrate (Cas) or p130Cas) is an adaptor protein that promotes protein-protein interactions, leading to the multiprotein complexes. The interaction of ?BCAR1/p130Cas with other proteins modulates cell motility, survial and proliferation. BCAR1/P130Cas is one of the main phosphorylation targets of the PTK2/SRC complex. The BCAR1 SH3 domain binds to PR1 and PR2 (‘PxxP’) domains in the PTK2 C-terminal domain.

Literature References
PubMed ID Title Journal Year
8649368 Introduction of p130cas signaling complex formation upon integrin-mediated cell adhesion: a role for Src family kinases

Vuori, K, Hirai, H, Aizawa, S, Ruoslahti, E

Mol. Cell. Biol. 1996
16581250 p130Cas: a versatile scaffold in signaling networks

Defilippi, P, Di Stefano, P, Cabodi, S

Trends Cell Biol 2006
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