oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]

Stable Identifier
R-HSA-372819
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

PCK2 (phosphoenolcarboxykinase), located in the mitochondrial matrix, catalyzes the physiologically irreversible reaction of oxaloacetate and GTP to form phosphoenolpyruvate, GDP, and CO2 (Modaressi et al. 1996, 1998).

Literature References
PubMed ID Title Journal Year
9657976 Human mitochondrial phosphoenolpyruvate carboxykinase 2 gene. Structure, chromosomal localization and tissue-specific expression

Modaressi, S, Brechtel, K, Christ, B, Jungermann, K

Biochem J 1998
8645161 Molecular cloning, sequencing and expression of the cDNA of the mitochondrial form of phosphoenolpyruvate carboxykinase from human liver

Modaressi, S, Christ, B, Bratke, J, Zahn, S, Heise, T, Jungermann, K

Biochem J 1996
Participants
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
phosphoenolpyruvate carboxykinase (GTP) activity of PCK2 [mitochondrial matrix]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed