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UBE2I-G92-SUMO3 [nucleoplasm]
Stable Identifier
R-HSA-3730611
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Small ubiquitin-related modifier 3, SUMO3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
Nucleotide Excision Repair (Homo sapiens)
Global Genome Nucleotide Excision Repair (GG-NER) (Homo sapiens)
Formation of Incision Complex in GG-NER (Homo sapiens)
SUMOylation of XPC (Homo sapiens)
SUMO1,2,3:UBE2I [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
Processing and activation of SUMO (Homo sapiens)
SUMO is transferred from E1 to E2 (UBE2I, UBC9) (Homo sapiens)
Transfer of SUMO3 from E1 to UBE2I (UBC9) (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of DNA damage response and repair proteins (Homo sapiens)
CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS1,4 SUMOylates BRCA1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS4 SUMOylates PARP1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of BLM with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of MDC1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of PML with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of RPA1 (RPA70) with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of TDG with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of DNA replication proteins (Homo sapiens)
PIAS4 SUMOylates TOP2A with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B) (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of chromatin organization proteins (Homo sapiens)
PIAS1 SUMOylates SATB1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates SATB2 with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
RANBP2 SUMOylates HDAC4 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of Histone H4 with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of immune response proteins (Homo sapiens)
PIAS3 SUMOylates RELA with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS1 SUMOylates THRB with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS2-2 SUMOylates THRA with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS4 SUMOylates NR4A2 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of NR1I2 with SUMO3 (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
PIAS1 SUMOylates SAFB with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PRC1 SUMOylates CTBP1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of NPM1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
SUMOylation of transcription factors (Homo sapiens)
MDM2 SUMOylates TP53 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
PIAS1,3,4 SUMOylate MTA1 with SUMO2,3 (Homo sapiens)
UBE2I:SUMO2,UBE2I:SUMO3 [nucleoplasm] (Homo sapiens)
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
UBE2I-G92-SUMO3 [nucleoplasm] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
12383504
Molecular features of human ubiquitin-like SUMO genes and their encoded proteins
Su, HL
,
Li, SS
Gene
2002
External Reference Information
External Reference
UniProt:P55854 SUMO3
Gene Names
SUMO3, SMT3A, SMT3H1
Chain
chain:1-92, propeptide:93-103
Reference Genes
BioGPS Gene:6612 SUMO3
COSMIC (genes):SUMO3 SUMO3
CTD Gene:6612 SUMO3
dbSNP Gene:6612 SUMO3
ENSEMBL:ENSG00000184900 SUMO3
HGNC:11124 SUMO3
KEGG:hsa:6612 SUMO3
Monarch:6612 SUMO3
NCBI Gene:6612 SUMO3
OMIM:602231 SUMO3
UCSC:P55854 SUMO3
Reference Transcript
RefSeq:NM_001286416.1 SUMO3
RefSeq:NM_006936.2 SUMO3
Other Identifiers
11721797_at
11721798_a_at
11764238_at
16926433
200739_PM_s_at
200739_s_at
200740_PM_s_at
200740_s_at
38738_at
3934670
3934671
3934672
3934673
3934674
3934676
3934677
3934678
3934682
3934683
3934684
3934685
3934686
3934688
3934689
6612
8070811
A_23_P102937
A_24_P245767
GE60218
GO:0000776
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0016605
GO:0016925
GO:0031386
GO:0043226
GO:0043392
GO:0044389
GO:1900180
HMNXSV003052673
Hs.85119.0.A1_3p_a_at
ILMN_1725642
PH_hs_0004814
PH_hs_0031377
TC21000536.hg
X99584_at
g5902095_3p_a_at
Participates
as a component of
SUMO3:UBE2I [nucleoplasm] (Homo sapiens)
Other forms of this molecule
SUMO3 [nucleoplasm]
lysyl-G92-SUMOyl-K11-SUMO3 [nucleoplasm]
UBA2-G92-SUMO3 [nucleoplasm]
SUMO3(1-103) [nucleoplasm]
Inferred To
Sumo [nucleoplasm]
(Drosophila melanogaster)
UBE2I-G92-SUMO3 [nucleoplasm]
(Dictyostelium discoideum)
UBE2I-G92-SUMO3 [nucleoplasm]
(Plasmodium falciparum)
SUMO3 [nucleoplasm]
(Bos taurus)
SUMO3 [nucleoplasm]
(Gallus gallus)
SUMO3 [nucleoplasm]
(Sus scrofa)
sumo3 [nucleoplasm]
(Danio rerio)
sumo3 [nucleoplasm]
(Xenopus tropicalis)
Sumo3 [nucleoplasm]
(Mus musculus)
Sumo3 [nucleoplasm]
(Rattus norvegicus)
Modified Residues
Name
Inter-chain Crosslink via S-(glycyl)-L-cysteine (Cys-Gly) at 92 and 93
Coordinate
92
PsiMod Name
S-(glycyl)-L-cysteine (Cys-Gly)
PsiMod Definition
A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.
Cross References
RefSeq
NP_008867.2
,
NP_001273345.1
OpenTargets
ENSG00000184900
ENSEMBL
ENST00000411651
,
ENST00000332859
,
ENSP00000330343
,
ENSP00000409666
HPA
ENSG00000184900-SUMO3
PRO
P55854
Pharos - Targets
P55854
GlyGen
P55854
PDB
2MP2
,
6K5R
,
7ZJU
,
1U4A
,
7R2E
,
2IO1
,
6NNQ
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9HC62 SENP2
1
SENP2 [nucleoplasm]
(R-HSA-2984298)
0.799
7
UniProt:Q5W0Q7 USPL1
0.782
17
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
0.669
3
UniProt:Q6PEW1 ZCH12
0.666
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
9
UniProt:P54253 ATX1
0.556
6
UniProt:Q96IT1 ZNF496
1
ZNF496 [nucleoplasm]
(R-HSA-1247860)
0.556
3
IntAct:EBI-16436244 CCSB ORF ID
0.556
3
UniProt:Q86T24 KAISO
0.556
3
UniProt:O15060 ZBT39
0.556
3
UniProt:A4D161 F221A
0.556
3
UniProt:Q99700-5 Q997005
0.556
3
UniProt:P62990 UBIQ
0.544
2
UniProt:P23497 SP100
3
polySUMO2-K297-SP100 [nucleoplasm]
(R-HSA-3000454)
monoSUMO1-K297-SP100 [nucleoplasm]
(R-HSA-3000382)
SP100 [nucleoplasm]
(R-HSA-1031705)
0.524
2
UniProt:O43290 SART1
1
SART1 [nucleoplasm]
(R-HSA-4615999)
0.499
2
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.499
2
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.463
2
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