Reactome | CCR4 [plasma membrane]

CCR4 [plasma membrane]

Stable Identifier

R-HSA-373090

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

C-C chemokine receptor type 4, CCR4_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Chemokine receptors bind chemokines (Homo sapiens)
        
        Receptors CCR3, 4 and 5 bind CCL5 ligand (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)
        
        CCR3,4,5:CCL5(24-91) [plasma membrane] (Homo sapiens)
        
        CCR3,4,5 [plasma membrane] (Homo sapiens)
        
        CCR4 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P51679 CCR4

Gene Names

CCR4, CMKBR4

Chain

chain:1-360

Reference Genes

BioGPS Gene:1233 CCR4

COSMIC (genes):CCR4 CCR4

CTD Gene:1233 CCR4

dbSNP Gene:1233 CCR4

ENSEMBL:ENSG00000183813 CCR4

ENSEMBL_homo_sapiens_GENE:ENSG00000183813.7 CCR4

HGNC:1605 CCR4

KEGG Gene (Homo sapiens):1233 CCR4

Monarch:1233 CCR4

NCBI Gene:1233 CCR4

OMIM:604836 CCR4

UCSC:P51679 CCR4

Reference Transcript

Other Identifiers

11736720_at

11759215_at

1233

16938707

208376_PM_at

208376_at

2616132

2616134

2616135

2616136

2616137

2616138

2616139

2616140

390_at

8078442

A_14_P115503

A_23_P72989

GE80336

GO:0001764

GO:0002376

GO:0002507

GO:0004930

GO:0004950

GO:0005515

GO:0005886

GO:0006935

GO:0006954

GO:0006955

GO:0007165

GO:0007186

GO:0007204

GO:0009617

GO:0009897

GO:0016020

GO:0016493

GO:0019722

GO:0019957

GO:0023052

GO:0030154

GO:0043025

GO:0048856

GO:0048870

GO:0048872

GO:0050927

GO:0060089

GO:0060326

GO:0070098

GO:1904936

HMNXSV003005613

ILMN_2086143

PH_hs_0032055

TC03000164.hg

X85740_at

g5031626_3p_at

Participates

as a member of

CCR3,4,5 [plasma membrane] (Homo sapiens)

Inferred To

CCR4 [plasma membrane] (Bos taurus)

CCR4 [plasma membrane] (Gallus gallus)

CCR4 [plasma membrane] (Sus scrofa)

Ccr4 [plasma membrane] (Mus musculus)

Ccr4 [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_005499.1, XP_016861176.1

ZINC - World Drugs

CCR4_HUMAN

Guide to Pharmacology - Targets

OpenTargets

ENSG00000183813

ZINC - FDA approved

CCR4_HUMAN

ZINC - Substances

CCR4_HUMAN

ZINC target

P51679

ZINC - Biogenic

CCR4_HUMAN

PRO

P51679

ZINC - Investigational

CCR4_HUMAN

ZINC - Metabolites

CCR4_HUMAN

GeneCards

P51679

HPA

ENSG00000183813-CCR4

Ensembl

ENSG00000183813, ENSP00000332659, ENST00000330953

Pharos - Targets

P51679

ZINC - Predictions - Purchasable

CCR4_HUMAN

HMDB Protein

HMDBP07577