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XCR1 [plasma membrane]
Stable Identifier
R-HSA-373109
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Chemokine XC receptor 1, XCR1_HUMAN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (q) signalling events (Homo sapiens)
Liganded Gq-activating GPCRs bind inactive heterotrimeric Gq (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
Liganded Gq/11-activating GPCRs act as GEFs for Gq/11 (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gq complex dissociates (Homo sapiens)
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11:Heterotrimeric G-protein Gq (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gq/11 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
XCR1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P46094 XCR1
Gene Names
XCR1, CCXCR1, GPR5
Chain
chain:1-333
Reference Genes
BioGPS Gene:2829 XCR1
COSMIC (genes):XCR1 XCR1
CTD Gene:2829 XCR1
dbSNP Gene:2829 XCR1
ENSEMBL:ENSG00000173578 XCR1
ENSEMBL_homo_sapiens_GENE:ENSG00000173578.9 XCR1
HGNC:1625 XCR1
KEGG Gene (Homo sapiens):2829 XCR1
Monarch:2829 XCR1
NCBI Gene:2829 XCR1
OMIM:600552 XCR1
UCSC:P46094 XCR1
Reference Transcript
RefSeq:XM_017006199.1 XCR1
RefSeq:XM_017006196.1 XCR1
RefSeq:NM_001024644.1 XCR1
RefSeq:XM_017006197.1 XCR1
RefSeq:XM_017006200.1 XCR1
RefSeq:NM_005283.2 XCR1
RefSeq:XM_017006201.1 XCR1
RefSeq:XM_017006198.1 XCR1
Other Identifiers
11738162_a_at
1561226_PM_at
1561226_at
16952868
221468_PM_at
221468_at
2672071
2672072
2672076
2672077
2672078
2672079
2672080
2829
54101_at
8086595
A_23_P18246
GE80796
GO:0002376
GO:0004930
GO:0004950
GO:0005515
GO:0005886
GO:0006935
GO:0006954
GO:0006955
GO:0007165
GO:0007186
GO:0007187
GO:0007204
GO:0009897
GO:0016020
GO:0016493
GO:0019722
GO:0019957
GO:0023052
GO:0034097
GO:0048870
GO:0051209
GO:0055065
GO:0055085
GO:0060089
GO:0060326
GO:0070098
HMNXSV003027303
Hs2.128375.1.S1_3p_s_at
ILMN_1764034
ILMN_1773238
ILMN_1846001
ILMN_2407954
PH_hs_0031677
PH_hs_0032310
TC03001354.hg
TC03002886.hg
TC03002887.hg
g4885338_3p_at
p26203
Participates
as an input of
Receptor CXC1 binds to the ligands lymphotactin and cytokine SCM-1 beta (Homo sapiens)
as a member of
GPCRs that activate Gq/11 [plasma membrane] (Homo sapiens)
as a component of
XCR1:XCL1,XCL2 [plasma membrane] (Homo sapiens)
Inferred To
npr-32 [plasma membrane]
(Caenorhabditis elegans)
xcr1 [plasma membrane]
(Xenopus tropicalis)
XCR1 [plasma membrane]
(Bos taurus)
XCR1 [plasma membrane]
(Canis familiaris)
XCR1 [plasma membrane]
(Sus scrofa)
CCXCR1-L [plasma membrane]
(Gallus gallus)
Xcr1 [plasma membrane]
(Mus musculus)
Xcr1 [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_005274.1
,
XP_016861688.1
,
NP_001019815.1
,
XP_016861687.1
,
XP_016861690.1
,
XP_016861685.1
,
XP_016861686.1
,
XP_016861689.1
Guide to Pharmacology - Targets
75
OpenTargets
ENSG00000173578
GeneCards
P46094
HPA
ENSG00000173578-XCR1
Ensembl
ENST00000309285
,
ENST00000395946
,
ENSG00000173578
,
ENSP00000507745
,
ENST00000683768
,
ENSP00000379277
,
ENSP00000310405
PRO
P46094
Pharos - Targets
P46094
HMDB Protein
HMDBP08102
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H8W4 PKHF2
0.556
3
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