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CX3CL1 [extracellular region]
Stable Identifier
R-HSA-373368
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
Fractalkine, X3CL1_HUMAN, Soluble CX3CL1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Chemokine receptors bind chemokines (Homo sapiens)
CX3CR1 binds CX3CL1 (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
CX3CR1:CX3CL1 [plasma membrane] (Homo sapiens)
CX3CL1 [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78423 CX3CL1
Gene Names
CX3CL1, FKN, NTT, SCYD1, A-152E5.2
Chain
signal peptide:1-24, chain:25-397, chain:25-339
Reference Genes
BioGPS Gene:6376 CX3CL1
COSMIC (genes):CX3CL1 CX3CL1
CTD Gene:6376 CX3CL1
dbSNP Gene:6376 CX3CL1
ENSEMBL:ENSG00000006210 CX3CL1
HGNC:10647 CX3CL1
KEGG Gene (Homo sapiens):6376 CX3CL1
Monarch:6376 CX3CL1
NCBI Gene:6376 CX3CL1
OMIM:601880 CX3CL1
UCSC:P78423 CX3CL1
Reference Transcript
RefSeq:NM_002996.4 CX3CL1
Other Identifiers
11734551_a_at
11734552_a_at
16819484
203687_at
3662697
3662698
3662703
3662704
3662705
3662706
3662707
3662708
3662709
6376
7996027
823_at
A_23_P37727
A_24_P381901
A_24_P390495
GE59499
GO:0001774
GO:0001954
GO:0002052
GO:0002376
GO:0002523
GO:0002548
GO:0002931
GO:0003674
GO:0005102
GO:0005125
GO:0005178
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005886
GO:0006464
GO:0006810
GO:0006935
GO:0006950
GO:0006952
GO:0006954
GO:0006955
GO:0007010
GO:0007155
GO:0007165
GO:0007186
GO:0007267
GO:0007568
GO:0008009
GO:0008150
GO:0008219
GO:0008283
GO:0008284
GO:0009058
GO:0009986
GO:0010812
GO:0010976
GO:0015031
GO:0016020
GO:0016021
GO:0016322
GO:0019221
GO:0021700
GO:0022607
GO:0030154
GO:0030336
GO:0030593
GO:0030595
GO:0031664
GO:0031737
GO:0032233
GO:0032690
GO:0032691
GO:0032715
GO:0032720
GO:0032914
GO:0033622
GO:0034330
GO:0034641
GO:0035425
GO:0040011
GO:0042056
GO:0042060
GO:0042592
GO:0042995
GO:0043005
GO:0043025
GO:0043066
GO:0043123
GO:0043410
GO:0043547
GO:0044297
GO:0045237
GO:0045766
GO:0045944
GO:0048020
GO:0048167
GO:0048245
GO:0048246
GO:0048247
GO:0048471
GO:0048646
GO:0048661
GO:0048856
GO:0048870
GO:0050729
GO:0050767
GO:0050902
GO:0050918
GO:0051041
GO:0051092
GO:0051281
GO:0051897
GO:0055085
GO:0060055
GO:0060326
GO:0061518
GO:0065003
GO:0070050
GO:0070098
GO:0070374
GO:0071346
GO:0071347
GO:0071356
GO:0098609
GO:0098883
GO:0110091
GO:1900450
GO:1903721
GO:1903979
GO:1904141
GO:1904468
GO:2001223
GO:2001234
GO:2001240
ILMN_1654072
PH_hs_0035471
TC16000488.hg
U84487_at
g4506856_3p_s_at
Participant Of
input
CX3CR1 binds CX3CL1
hasComponent
CX3CR1:CX3CL1 [plasma membrane]
Inferred To
I3L9Z6 [extracellular region] (Sus scrofa)
Q4KS30 [extracellular region] (Gallus gallus)
CCL4 [extracellular region] (Gallus gallus)
CX3CL1 [extracellular region] (Canis familiaris)
ccl38a.4 [extracellular region] (Danio rerio)
A0A3Q1LPV5 [extracellular region] (Bos taurus)
ccl36.1 [extracellular region] (Danio rerio)
ccl38a.5 [extracellular region] (Danio rerio)
ccl34b.8 [extracellular region] (Danio rerio)
ccl34b.9 [extracellular region] (Danio rerio)
ccl35.2 [extracellular region] (Danio rerio)
Cx3cl1 [extracellular region] (Mus musculus)
Cx3cl1 [extracellular region] (Rattus norvegicus)
ccl35.1 [extracellular region] (Danio rerio)
ccl38.1 [extracellular region] (Danio rerio)
ccl38.6 [extracellular region] (Danio rerio)
Homologues of CX3CL1 [extracellular region] (Danio rerio)
Homologues of CX3CL1 [extracellular region] (Gallus gallus)
Q5IEZ5 [extracellular region] (Gallus gallus)
ccl20b [extracellular region] (Danio rerio)
Cross References
RefSeq
NP_002987.1
OpenTargets
ENSG00000006210
GeneCards
P78423
HPA
ENSG00000006210-CX3CL1
Ensembl
ENSG00000006210
,
ENSP00000006053
,
ENST00000006053
PRO
P78423
PDB
4XT3
,
5WB2
,
1F2L
,
4XT1
,
1B2T
,
3ONA
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05106 ITGB3
3
ITGB3(27-?) [platelet alpha granule membrane]
(R-HSA-114512)
p-T779-ITGB3 [plasma membrane]
(R-HSA-432107)
ITGB3 [plasma membrane]
(R-HSA-57600)
0.718
7
UniProt:P69332 US28
0.645
4
UniProt:A0A061IJ01 A0A061IJ01
0.589
4
UniProt:P02679 FGG
5
p-FGG [endoplasmic reticulum lumen]
(R-HSA-8956993)
FGG [platelet alpha granule lumen]
(R-HSA-140922)
FGG [endoplasmic reticulum lumen]
(R-HSA-8956692)
FGG [plasma membrane]
(R-HSA-140918)
FGG [extracellular region]
(R-HSA-140585)
0.524
3
UniProt:P05556 ITGB1
2
ITGB1 [endosome membrane]
(R-HSA-9611157)
ITGB1 [plasma membrane]
(R-HSA-57596)
0.524
2
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