Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
ANK1 [cytosol]
Stable Identifier
R-HSA-373619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Ankyrin-G, Ankyrin-1
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
L1CAM interactions (Homo sapiens)
CHL1 interactions (Homo sapiens)
CHL1 interacts with Ankyrin-G (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
CHL1:Ankyrin-G [plasma membrane] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Interaction between L1 and Ankyrins (Homo sapiens)
Ankyrins link voltage-gated sodium and potassium channels to spectrin and L1 (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin:KCNQ2,3, SCNAs:SCNBs [plasma membrane] (Homo sapiens)
NFASC:NRCAM:ANK1-3:SPTA:SPTB:F-actin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
L1 dimer binds Ankyrin (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
L1 linked to actin cytoskeleton by ankyrin (Homo sapiens)
L1 dimer:Ankyrin:Spectrin:F-actin [plasma membrane] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Phosphorylation of Y1229 in L1 (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
L1 trans-homodimer:Ankyrin [plasma membrane] (Homo sapiens)
ANK1-3 [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Neurofascin interactions (Homo sapiens)
Neurofascin binds Ankyrin-G (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Neurofascin:Ankyrin-G complex [plasma membrane] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Phosphorylation of Neurofascin (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Trans neurofascin dimer:ankyrin-G [plasma membrane] (Homo sapiens)
Neurofascin:Ankyrin-G complex [plasma membrane] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Trans-homodimerization of Neurofascin (Homo sapiens)
Neurofascin:Ankyrin-G complex [plasma membrane] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Trans neurofascin dimer:ankyrin-G [plasma membrane] (Homo sapiens)
Neurofascin:Ankyrin-G complex [plasma membrane] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
NrCAM interactions (Homo sapiens)
NrCAM binds Ankyrin-G (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
NrCAM:Ankyrin-G [plasma membrane] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Asparagine N-linked glycosylation (Homo sapiens)
Transport to the Golgi and subsequent modification (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Vesicle-mediated transport (Homo sapiens)
Membrane Trafficking (Homo sapiens)
ER to Golgi Anterograde Transport (Homo sapiens)
COPI-mediated anterograde transport (Homo sapiens)
ARFGAP, cargo, v-SNAREs and p24 proteins bind nascent COPI complex (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
ARFGAPs stimulate ARF GTPase activity (Homo sapiens)
RAB1:GTP:GBF1:USO1:ARF:GTP:coatomer:ARFGAP1,2,3:PalmC-YKT6:p24 dimers:cargo:spectrin:ankyrin [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
COPI vesicle uncoating (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
ERGIC-to-Golgi vesicles bind dynein:dynactin (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
Vesicle is tethered through binding GOLGA2:GORASP1, GOLGB1 and the COG complex (Homo sapiens)
RAB1:GTP:USO1 coatomer:PalmC-YKT6:p24 dimers:cargo:anykrin:spectrin:dynein:dynactin:microtubules [transport vesicle] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [transport vesicle] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
cis-Golgi t-SNAREs bind YKT6 on tethered vesicle (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
RAB1:GTP:USO1:coatomer:p24 dimers:cargo:spectrin:ankyrin:COG complex:GOLGA2:GORASP1:TMEM115:cis-SNARE complex [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin:COG complex:GOLGA2:GORASP1:GOLGB1:TMEM115 [Golgi membrane] (Homo sapiens)
RAB1:GTP:USO1:coatomer:PalmC-YKT6:p24 dimers:cargo:spectrin:anykrin [Golgi membrane] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
ANK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P16157 ANK1
Gene Names
ANK1, ANK
Chain
chain:1-1881
Reference Genes
BioGPS Gene:286 ANK1
COSMIC (genes):ANK1 ANK1
CTD Gene:286 ANK1
dbSNP Gene:286 ANK1
ENSEMBL:ENSG00000029534 ANK1
ENSEMBL_homo_sapiens_GENE:ENSG00000029534.22 ANK1
HGNC:492 ANK1
KEGG Gene (Homo sapiens):286 ANK1
Monarch:286 ANK1
NCBI Gene:286 ANK1
OMIM:612641 ANK1
UCSC:P16157 ANK1
Reference Transcript
RefSeq:NM_020480.4 ANK1
RefSeq:NM_001142446.1 ANK1
RefSeq:NM_020475.2 ANK1
RefSeq:NM_020478.4 ANK1
RefSeq:NM_020476.2 ANK1
RefSeq:NM_000037.3 ANK1
RefSeq:NM_001142445.1 ANK1
RefSeq:NM_020477.2 ANK1
Other Identifiers
11734352_a_at
11734353_x_at
11734354_s_at
11740098_a_at
11741071_a_at
11747185_x_at
11755227_x_at
17076634
205389_PM_s_at
205389_s_at
205390_PM_s_at
205390_s_at
205391_PM_x_at
205391_x_at
207087_PM_x_at
207087_x_at
208352_PM_x_at
208352_x_at
208353_PM_x_at
208353_x_at
286
3132941
3132942
3132943
3132944
3132945
3132946
3132947
3132948
3132949
3132950
3132956
3132957
3132959
3132960
3132961
3132962
3132963
3132964
3132965
3132967
3132968
3132969
3132974
3132975
3132976
3132977
3132986
3132988
3132989
3132991
3132992
3132995
3132996
3132998
3132999
3133000
3133001
3133002
3133003
3133004
3133006
3133008
3133009
3133010
3133011
3133012
3133014
3133015
3133016
3133017
3133018
3133019
3133020
3133021
3133022
3133023
3133024
3133025
3133026
3133027
3133029
3133030
3133033
3133038
3133048
3133049
3133120
32152_at
59028_at
8150439
A_23_P216108
A_24_P162483
A_24_P162485
A_33_P3376321
GE61555
GO:0005198
GO:0005200
GO:0005515
GO:0005737
GO:0005783
GO:0005829
GO:0005856
GO:0005886
GO:0006887
GO:0006888
GO:0007010
GO:0007163
GO:0007165
GO:0008092
GO:0008093
GO:0009898
GO:0010638
GO:0014731
GO:0016020
GO:0016192
GO:0016323
GO:0016529
GO:0019899
GO:0019903
GO:0023052
GO:0030018
GO:0030507
GO:0030673
GO:0031430
GO:0031672
GO:0042383
GO:0043005
GO:0043226
GO:0044325
GO:0045199
GO:0045211
GO:0051117
GO:0051179
GO:0060090
GO:0072659
GO:0170014
HMNXSV003007701
ILMN_1684694
ILMN_2317186
PH_hs_0021286
TC08001171.hg
X16609_s_at
g10947039_3p_a_at
g10947043_3p_a_at
Participates
as a component of
NrCAM:Ankyrin-G [plasma membrane] (Homo sapiens)
CHL1:Ankyrin-G [plasma membrane] (Homo sapiens)
Neurofascin:Ankyrin-G complex [plasma membrane] (Homo sapiens)
as an input of
NrCAM binds Ankyrin-G (Homo sapiens)
CHL1 interacts with Ankyrin-G (Homo sapiens)
Neurofascin binds Ankyrin-G (Homo sapiens)
as an output of
Phosphorylation of Neurofascin (Homo sapiens)
as a member of
ANK1-3 [cytosol] (Homo sapiens)
Ankyrin [cytosol] (Homo sapiens)
Inferred To
Ank1 [cytosol]
(Mus musculus)
Ank1 [cytosol]
(Rattus norvegicus)
ANK1 [cytosol]
(Canis familiaris)
ANK1 [cytosol]
(Dictyostelium discoideum)
ANK1 [cytosol]
(Sus scrofa)
Ank [cytosol]
(Drosophila melanogaster)
Homologues of ANK1 [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_065210.2
,
NP_065208.2
,
NP_065211.2
,
NP_065209.2
,
NP_065213.2
,
NP_001135917.1
,
NP_000028.3
,
NP_001135918.1
OpenTargets
ENSG00000029534
HPA
ENSG00000029534-ANK1
GeneCards
P16157
Ensembl
ENSP00000430368
,
ENST00000522543
,
ENSP00000289734
,
ENSP00000339620
,
ENSP00000265709
,
ENSP00000319123
,
ENST00000347528
,
ENST00000348036
,
ENST00000289734
,
ENSP00000297744
,
ENST00000265709
,
ENSG00000029534
,
ENST00000314214
PRO
P16157
Pharos - Targets
P16157
Orphanet
15930
PDB
3UD2
,
2YVI
,
2YQF
,
8CTE
,
7V0S
,
7UZQ
,
7TW5
,
7V0X
,
8CSL
,
7TW3
,
8CS9
,
7V0K
,
8CSV
,
3KBU
,
7TW6
,
3KBT
,
7UZU
,
3F59
,
7V0M
,
1N11
,
3UD1
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q5VST9-3 OBSCN
0.557
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text