Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane]
Stable Identifier
R-HSA-373636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-Nephrin
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Nephrin family interactions (Homo sapiens)
Nephrin binds CD2AP (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Nephrin binds NCK (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Nephrin interacts with Podocin (Homo sapiens)
Podocin:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Nephrin mediated activation of N-WASP (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK:N-WASP [plasma membrane] (Homo sapiens)
NEPH1:p-Nephrin:Fyn:NCK [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
Phosphorylation of nephrin by FYN (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
p85 associates with both p-Nephrin and CD2AP (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
PI3K:CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
CD2AP:p-Nephrin:Fyn:NEPH1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL:FYN [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:KIRREL [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane] (Homo sapiens)
p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:O60500 NPHS1
Gene Names
NPHS1, NPHN
Chain
signal peptide:1-22, chain:23-1241
Reference Genes
BioGPS Gene:4868 NPHS1
COSMIC (genes):NPHS1 NPHS1
CTD Gene:4868 NPHS1
dbSNP Gene:4868 NPHS1
ENSEMBL:ENSG00000161270 NPHS1
HGNC:7908 NPHS1
KEGG Gene (Homo sapiens):4868 NPHS1
Monarch:4868 NPHS1
NCBI Gene:4868 NPHS1
OMIM:602716 NPHS1
UCSC:O60500 NPHS1
Reference Transcript
RefSeq:NM_004646.3 NPHS1
Other Identifiers
0002510286
11737576_at
16871495
207673_3p_at
207673_at
31967_at
3860046
3860047
3860048
3860050
3860051
3860052
3860054
3860055
3860057
3860059
3860060
3860061
3860062
3860063
3860064
3860066
3860067
3860068
3860069
3860070
3860072
3860073
3860075
3860076
3860077
3860078
3860080
3860081
3860082
3860083
3860084
3860085
3860086
4868
76445_f_at
8036176
A_23_P5200
A_32_P13555
GE79939
GO:0000165
GO:0003674
GO:0005515
GO:0005575
GO:0005576
GO:0005615
GO:0005886
GO:0005887
GO:0005925
GO:0006464
GO:0006810
GO:0006950
GO:0007010
GO:0007155
GO:0007165
GO:0007254
GO:0007275
GO:0007517
GO:0007519
GO:0007520
GO:0007588
GO:0008092
GO:0008150
GO:0016020
GO:0016021
GO:0017022
GO:0022607
GO:0030154
GO:0030198
GO:0030838
GO:0032836
GO:0035418
GO:0036057
GO:0042995
GO:0043226
GO:0044062
GO:0048646
GO:0048856
GO:0065003
GO:0070062
GO:0072015
ILMN_1681116
ILMN_1749147
PH_hs_0030834
TC19001456.hg
g4758821_3p_at
g4758821_3p_x_at
Participant Of
hasComponent
p-Y1158,Y1176,Y1193,Y1217-NPHS1:NPHS1 [plasma membrane]
Other forms of this molecule
NPHS1 [plasma membrane]
Inferred To
phospho-Nphs1 [plasma membrane] (Mus musculus)
phospho-Nphs1 [plasma membrane] (Rattus norvegicus)
phospho-NPHS1 [plasma membrane] (Canis familiaris)
phospho-NPHS1 [plasma membrane] (Sus scrofa)
phospho-p-Y1158,Y1176,Y1193,Y1217-NPHS1 [plasma membrane] (Xenopus tropicalis)
phospho-nphs1 [plasma membrane] (Danio rerio)
Modified Residues
Name
O4'-phospho-L-tyrosine at 1176
Coordinate
1176
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1193
Coordinate
1193
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1217
Coordinate
1217
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 1158
Coordinate
1158
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_004637.1
OpenTargets
ENSG00000161270
GeneCards
O60500
HPA
ENSG00000161270-NPHS1
Ensembl
ENST00000353632
,
ENST00000378910
,
ENSP00000368190
,
ENSG00000161270
,
ENSP00000343634
PRO
O60500
Orphanet
16566
PDB
4ZRT
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P46940 IQGAP1
3
IQGAP1 [secretory granule membrane]
(R-HSA-6804803)
IQGAP1 [cytosol]
(R-HSA-5626371)
IQGAP1 [plasma membrane]
(R-HSA-381681)
0.556
5
UniProt:P16333 NCK1
2
NCK1 [cytosol]
(R-HSA-197954)
NCK1 [plasma membrane]
(R-HSA-202992)
0.524
3
UniProt:O43639 NCK2
1
NCK2 [cytosol]
(R-HSA-204885)
0.463
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text