Caspase-9 binds DCC:DIP13alpha complex

Stable Identifier
R-HSA-373700
Type
Reaction [binding]
Species
Homo sapiens
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Caspase-9 binds DCC:DIP13alpha complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The ADD domain of DCC complexed with DIP13alpha interacts with the initiator caspase-9, leading to caspase activation and caspase-dependent cell death. DIP13alpha appears to function as a required adaptor to mediate DCC-caspase-9 interaction.
Literature References
PubMed ID Title Journal Year
12011067 Mediation of the DCC apoptotic signal by DIP13 alpha

Wu, R, Yao, F, Liu, J, Finley RL, Jr, Morgan, M, Chen, YQ, Thorburn, A

J Biol Chem 2002
11248093 The dependence receptor DCC (deleted in colorectal cancer) defines an alternative mechanism for caspase activation

Mehlen, P, Bredesen, DE, Ye, X, Shin, H, Corset, V, Granger, L, Forcet, C

Proc Natl Acad Sci U S A 2001
Participants
Input
Output
Participates
as an event of
Orthologous Events
Caspase-9 binds DCC:DIP13alpha complex (Bos taurus)
Caspase-9 binds DCC:DIP13alpha complex (Canis familiaris)
Caspase-9 binds DCC:DIP13alpha complex (Mus musculus)
Caspase-9 binds DCC:DIP13alpha complex (Rattus norvegicus)
Caspase-9 binds DCC:DIP13alpha complex (Sus scrofa)
Authored
Garapati, P V  (2008-07-16)
Reviewed
Cooper, HM  (2010-02-16)
Created
Garapati, P V  (2008-07-16)
Cite Us!