Reactome | Contactin-1 (CNTN1) binds NOTCH1

Contactin-1 (CNTN1) binds NOTCH1

Stable Identifier

R-HSA-373706

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Contactin-1 (CNTN1) is composed of six Ig domains followed by four FNIII repeats and is anchored to the membrane via a glycosyl-phosphatidylinositol (GPI) tail. It is expressed transiently during CNS and PNS development both as GPI-anchored and soluble forms. CNTN1 is a physiological ligand of NOTCH, shown to bind and activate NOTCH1 and NOTCH2 in trans. The activation of NOTCH signaling by CNTN1 is Deltex (DTX)-dependent and promotes oligodendrocyte maturation and myelination.

Literature References

PubMed ID	Title	Journal	Year
14567914	F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation Small, D, Cui, XY, Ling, EA, Hirai, H, Pallen, CJ, Okano, H, Karsak, M, Xiao, ZC, Maciag, T, Ang, BT, Takeda, Y, Watanabe, K, Duka, T, Ng, YK, Hu, QD, Nakafuku, M, Sankar, N, Aster, JC, Chiba, S, Kopan, R, Schachner, M, Trifonova, R, Chia, W, Hu, WP	Cell	2003