Nephrin binds NCK

Stable Identifier
R-HSA-373724
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

Nephrin tyrosine phosphorylation regulates podocyte cell morphology via NCK adaptor proteins. NCK via its SH2 domain interacts with the three phosphotyrosines (1176, 1193 and 1217) on nephrin, and through its SH3 domain can recruit several other proteins involved in the regulation of the actin cytoskeleton such as N WASP, WIP, ARP2/3 and PAK to the slit diaphragm. The importance of this mechanism is the maintenance of the filtration barrier. When rapid actin polymerization and cytoskeletal reorganization is needed, for example during development or injury and repair, the level of nephrin phosphorylation increases and leads to recruitment of NCK and its downstream effectors to the cytoplasmic side of the slit diaphragm.

Literature References
PubMed ID Title Journal Year
16630808 Nck links nephrin to actin in kidney podocytes

Tryggvason, K, Pikkarainen, T, Patrakka, J

Cell 2006
16525419 Nck adaptor proteins link nephrin to the actin cytoskeleton of kidney podocytes

Jones, N, Blasutig, IM, Eremina, V, Ruston, JM, Bladt, F, Li, H, Huang, H, Larose, L, Li, SS, Takano, T, Quaggin, SE, Pawson, T

Nature 2006
19443634 Nck proteins maintain the adult glomerular filtration barrier

Jones, N, New, LA, Fortino, MA, Eremina, V, Ruston, J, Blasutig, IM, Aoudjit, L, Zou, Y, Liu, X, Yu, GL, Takano, T, Quaggin, SE, Pawson, T

J Am Soc Nephrol 2009
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