Nephrin trans-homophilic interaction

Stable Identifier
R-HSA-373732
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Foot processes are slender, actin rich protrusions of the cytoplasm that are anchored to the glomerular basement membrane. Adjacent foot processes are laterally interconnected by a highly specialized cell-cell junction, the slit diaphragm (SD). Nephrin (NPHS1) is the critical structural component within the slit diaphragm. Nephrin molecules of adjacent foot processes from neighboring podocytes interact with each other in the middle of the slit diaphragm forming a filter with a zipper like structure and with pores just the size of albumin on both sides of the midline density.

Participants
Participant Of
Orthologous Events