Nephrin trans-homophilic interaction

Stable Identifier
R-HSA-373732
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Foot processes are slender, actin rich protrusions of the cytoplasm that are anchored to the glomerular basement membrane. Adjacent foot processes are laterally interconnected by a highly specialized cell-cell junction, the slit diaphragm (SD). Nephrin (NPHS1) is the critical structural component within the slit diaphragm. Nephrin molecules of adjacent foot processes from neighboring podocytes interact with each other in the middle of the slit diaphragm forming a filter with a zipper like structure and with pores just the size of albumin on both sides of the midline density.

Literature References
PubMed ID Title Journal Year
10393930 Nephrin is specifically located at the slit diaphragm of glomerular podocytes

Ruotsalainen, V, Ljungberg, P, Wartiovaara, J, Lenkkeri, U, Kestilä, M, Jalanko, H, Holmberg, C, Tryggvason, K

Proc Natl Acad Sci U S A 1999
15545998 Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography

Wartiovaara, J, Ofverstedt, LG, Khoshnoodi, J, Zhang, J, Mäkelä, E, Sandin, S, Ruotsalainen, V, Cheng, RH, Jalanko, H, Skoglund, U, Tryggvason, K

J Clin Invest 2004
17893108 The nephrin-based slit diaphragm: new insight into the signalling platform identifies targets for therapy

Aaltonen, P, Holthofer, H

Nephrol Dial Transplant 2007
12660326 Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1

Gerke, P, Huber, TB, Sellin, L, Benzing, T, Walz, G

J Am Soc Nephrol 2003
14633607 Nephrin promotes cell-cell adhesion through homophilic interactions

Khoshnoodi, J, Sigmundsson, K, Ofverstedt, LG, Skoglund, U, Obrink, B, Wartiovaara, J, Tryggvason, K

Am J Pathol 2003
10541305 Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm

Tryggvason, K

J Am Soc Nephrol 1999
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