Reactome | Nephrin trans-homophilic interaction

Nephrin trans-homophilic interaction

Stable Identifier

R-HSA-373732

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Foot processes are slender, actin rich protrusions of the cytoplasm that are anchored to the glomerular basement membrane. Adjacent foot processes are laterally interconnected by a highly specialized cell-cell junction, the slit diaphragm (SD). Nephrin (NPHS1) is the critical structural component within the slit diaphragm. Nephrin molecules of adjacent foot processes from neighboring podocytes interact with each other in the middle of the slit diaphragm forming a filter with a zipper like structure and with pores just the size of albumin on both sides of the midline density.

Literature References

PubMed ID	Title	Journal	Year
15545998	Nephrin strands contribute to a porous slit diaphragm scaffold as revealed by electron tomography Wartiovaara, J, Ofverstedt, LG, Khoshnoodi, J, Zhang, J, Mäkelä, E, Sandin, S, Ruotsalainen, V, Cheng, RH, Jalanko, H, Skoglund, U, Tryggvason, K	J Clin Invest	2004
10393930	Nephrin is specifically located at the slit diaphragm of glomerular podocytes Ruotsalainen, V, Ljungberg, P, Wartiovaara, J, Lenkkeri, U, Kestilä, M, Jalanko, H, Holmberg, C, Tryggvason, K	Proc Natl Acad Sci U S A	1999
17893108	The nephrin-based slit diaphragm: new insight into the signalling platform identifies targets for therapy Aaltonen, P, Holthofer, H	Nephrol Dial Transplant	2007
12660326	Homodimerization and heterodimerization of the glomerular podocyte proteins nephrin and NEPH1 Gerke, P, Huber, TB, Sellin, L, Benzing, T, Walz, G	J Am Soc Nephrol	2003
14633607	Nephrin promotes cell-cell adhesion through homophilic interactions Khoshnoodi, J, Sigmundsson, K, Ofverstedt, LG, Skoglund, U, Obrink, B, Wartiovaara, J, Tryggvason, K	Am J Pathol	2003
10541305	Unraveling the mechanisms of glomerular ultrafiltration: nephrin, a key component of the slit diaphragm Tryggvason, K	J Am Soc Nephrol	1999