Reactome | Nephrin interacts with Podocin

Nephrin interacts with Podocin

Stable Identifier

R-HSA-373734

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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NPHS2 encodes podocin, a protein exclusively expressed in podocytes in developing and mature glomeruli. Podocin is a member of the stomatin protein family with a short N terminal domain, a membrane-anchoring region, and a cytosolic C-terminal domain. Podocin accumulates in an oligomeric form in lipid rafts of the slit diaphragm. The C-terminal domain of Podocin binds to the cytoplasmic domain of nephrin thus it may function as a scaffolding protein connecting nephrin with the actin cytoskeleton. Beside nephrin it was shown that podocin also interacts with several other SD proteins, hence forming functional microdomains

Literature References

PubMed ID	Title	Journal	Year
11562357	Interaction with podocin facilitates nephrin signaling Huber, TB, Kottgen, M, Schilling, B, Walz, G, Benzing, T	J Biol Chem	2001
14570703	Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains Huber, TB, Simons, M, Hartleben, B, Sernetz, L, Schmidts, M, Gundlach, E, Saleem, MA, Walz, G, Benzing, T	Hum Mol Genet	2003
11733557	Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin Schwarz, K, Simons, M, Reiser, J, Saleem, MA, Faul, C, Kriz, W, Shaw, AS, Holzman, LB, Mundel, P	J Clin Invest	2001