Nephrin interacts with Podocin

Stable Identifier
R-HSA-373734
Type
Reaction
Species
Homo sapiens
Compartment
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Summation

NPHS2 encodes podocin, a protein exclusively expressed in podocytes in developing and mature glomeruli. Podocin is a member of the stomatin protein family with a short N terminal domain, a membrane-anchoring region, and a cytosolic C-terminal domain. Podocin accumulates in an oligomeric form in lipid rafts of the slit diaphragm. The C-terminal domain of Podocin binds to the cytoplasmic domain of nephrin thus it may function as a scaffolding protein connecting nephrin with the actin cytoskeleton. Beside nephrin it was shown that podocin also interacts with several other SD proteins, hence forming functional microdomains

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Orthologous Events