Nephrin interacts with Podocin

Stable Identifier
R-HSA-373734
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

NPHS2 encodes podocin, a protein exclusively expressed in podocytes in developing and mature glomeruli. Podocin is a member of the stomatin protein family with a short N terminal domain, a membrane-anchoring region, and a cytosolic C-terminal domain. Podocin accumulates in an oligomeric form in lipid rafts of the slit diaphragm. The C-terminal domain of Podocin binds to the cytoplasmic domain of nephrin thus it may function as a scaffolding protein connecting nephrin with the actin cytoskeleton. Beside nephrin it was shown that podocin also interacts with several other SD proteins, hence forming functional microdomains

Literature References
PubMed ID Title Journal Year
14570703 Molecular basis of the functional podocin-nephrin complex: mutations in the NPHS2 gene disrupt nephrin targeting to lipid raft microdomains

Huber, TB, Simons, M, Hartleben, B, Sernetz, L, Schmidts, M, Gundlach, E, Saleem, MA, Walz, G, Benzing, T

Hum Mol Genet 2003
11562357 Interaction with podocin facilitates nephrin signaling

Huber, TB, Kottgen, M, Schilling, B, Walz, G, Benzing, T

J Biol Chem 2001
11733557 Podocin, a raft-associated component of the glomerular slit diaphragm, interacts with CD2AP and nephrin

Schwarz, K, Simons, M, Reiser, J, Saleem, MA, Faul, C, Kriz, W, Shaw, AS, Holzman, LB, Mundel, P

J Clin Invest 2001
Participants
Participant Of
Orthologous Events
Authored
Reviewed