Reactome: A Curated Pathway Database

Shootin-1 links L1 and retrograde actin flow

Stable Identifier
R-HSA-373736
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Shootin-1 acts as a linker protein, binding L1 to moving actin filaments in axonal growth cones. This interaction mediates the migration of L1 on the plasma membrane from P-domain to the C-domain of the growth cone and enhances neurite elongation.

Participants
Participant Of
Inferred From