Phosphorylation of nephrin by FYN

Stable Identifier
R-HSA-373747
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

Nephrin has eight putative phosphorylation sites, which nicely match with substrate sites for the Src kinase family. Nephrin, is tyrosine phosphorylated by the Src family tyrosine kinase, Fyn in developing and injured podocytes. Phosphorylation of three of these tyrosines (1176, 1193 and 1217) results in the formation of a preferred binding motif (YDXV) for the SH2 domain of the adaptor protein NCK, which is one of the bricks linking Nephrin to the cytoskeleton. Phosphorylation of tyrosine 1158 results in a binding motif for the p85 regulatory subunit of PI3K.

Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
protein tyrosine kinase activity of NPHS1 dimer:KIRREL:FYN [plasma membrane]
Physical Entity
Activity
Orthologous Events