Netrin-1 signaling

Stable Identifier
R-HSA-373752
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Pathway
Species
Homo sapiens
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Netrins are secreted proteins that play a crucial role in neuronal migration and in axon guidance during the development of the nervous system. To date, several Netrins have been described in mouse and humans: Netrin-1, -3/NTL2, -4/h and G-Netrins. Netrin-1 is the most studied member of the family and has been shown to play a crucial role in neuronal navigation during nervous system development mainly through its interaction with its receptors DCC and UNC5. Members of the Deleted in colorectal cancer (DCC) family- which includes DCC and Neogenin in vertebrates- mediate netrin-induced axon attraction, whereas the C. elegans UNC5 receptor and its four vertebrate homologs Unc5a-Unc5d mediate repulsion.

Literature References
PubMed ID Title Journal Year
10499167 The Deleted in Colorectal Cancer netrin guidance system: a molecular strategy for neuronal navigation

Cooper, HM, Gad, JM, Keeling, SL

Clin Exp Pharmacol Physiol 1999
18269208 Netrins and their receptors

Moore, SW, Tessier-Lavigne, M, Kennedy, TE

Adv Exp Med Biol 2007
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