Semaphorin interactions

Stable Identifier
R-HSA-373755
Type
Pathway
Species
Homo sapiens
Locations in the PathwayBrowser
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Summation

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins.

Literature References
PubMed ID Title Journal Year
12471249 Molecular mechanisms of axon guidance Science 2002
16939971 Semaphorins in axon regeneration: developmental guidance molecules gone wrong? Philos Trans R Soc Lond B Biol Sci 2006
18269210 Role of semaphorins during axon growth and guidance Adv Exp Med Biol 2007
18374575 Semaphorin signaling: progress made and promises ahead Trends Biochem Sci 2008
12593985 Semaphorin junction: making tracks toward neural connectivity Curr Opin Neurobiol 2003
Participants
Events
Participant Of
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Orthologous Events
Semaphorin interactions (Bos taurus)
Semaphorin interactions (Caenorhabditis elegans)
Semaphorin interactions (Canis familiaris)
Semaphorin interactions (Danio rerio)
Semaphorin interactions (Dictyostelium discoideum)
Semaphorin interactions (Drosophila melanogaster)
Semaphorin interactions (Gallus gallus)
Semaphorin interactions (Mus musculus)
Semaphorin interactions (Rattus norvegicus)
Semaphorin interactions (Saccharomyces cerevisiae)
Semaphorin interactions (Sus scrofa)
Semaphorin interactions (Taeniopygia guttata)
Semaphorin interactions (Xenopus tropicalis)