Reactome | Semaphorin interactions

Semaphorin interactions

Stable Identifier

R-HSA-373755

Type

Pathway

Species

Homo sapiens

Locations in the PathwayBrowser

Expand all

Summation

Semaphorins are a large family of cell surface and secreted guidance molecules divided into eight classes on the basis of their structures. They all have an N-terminal conserved sema domain. Semaphorins signal through multimeric receptor complexes that include other proteins such as plexins and neuropilins.

Literature References

PubMed ID	Title	Journal	Year
12471249	Molecular mechanisms of axon guidance Dickson, BJ	Science	2002
16939971	Semaphorins in axon regeneration: developmental guidance molecules gone wrong? Pasterkamp, RJ, Verhaagen, J	Philos Trans R Soc Lond B Biol Sci	2006
18269210	Role of semaphorins during axon growth and guidance Koncina, E, Roth, L, Gonthier, B, Bagnard, D	Adv Exp Med Biol	2007
18374575	Semaphorin signaling: progress made and promises ahead Zhou, Y, Gunput, RA, Pasterkamp, RJ	Trends Biochem Sci	2008
12593985	Semaphorin junction: making tracks toward neural connectivity Pasterkamp, RJ, Kolodkin, AL	Curr Opin Neurobiol	2003