Reactome | SDK interactions

SDK interactions

Stable Identifier

R-HSA-373756

DOI

10.3180/R-HSA-373756.1

Type

Pathway

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Sidekick-1 (SDK1) and sidekick-2 (SDK2) are cell adhesion molecules of the immunoglobulin superfamily expressed by nonoverlapping subsets of retinal neurons. They have been shown to function as neuronal targeting molecules, guiding developing neurons to specific synapses.
SDKs are concentrated at synapses that connect SDK-expressing pre- and postsynaptic partners, suggesting that their homophilic adhesion properties promote formation or stabilization of synapses.

SDKs promotes lamina-specific synaptic connections in the retina and are specifically required for the formation of neuronal circuits that detect motion (Krishnaswamy et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
20562105	Up-regulation of the homophilic adhesion molecule sidekick-1 in podocytes contributes to glomerulosclerosis Kurihara, H, Potla, U, Kaufman, L, Hata, Y, Dikiy, S, Coleman, S, Klotman, PE, He, JC, D'Agati, VD	J. Biol. Chem.	2010
12230981	Sidekicks: synaptic adhesion molecules that promote lamina-specific connectivity in the retina Weiner, JA, Sanes, JR, Yamagata, M	Cell	2002
27644106	Molecular basis of sidekick-mediated cell-cell adhesion and specificity Honig, B, Goodman, KM, Katsamba, PS, Sanes, JR, Sergeeva, AP, Jin, X, Ahlsén, G, Mannepalli, S, Shapiro, L, Yamagata, M	Elife	2016
18216854	Dscam and Sidekick proteins direct lamina-specific synaptic connections in vertebrate retina Sanes, JR, Yamagata, M	Nature	2008
15703275	Definition of the critical domains required for homophilic targeting of mouse sidekick molecules Kaufman, L, Hayashi, K, Klotman, PE, Ross, MD	FASEB J.	2005
20219992	Synaptic localization and function of Sidekick recognition molecules require MAGI scaffolding proteins Sanes, JR, Yamagata, M	J. Neurosci.	2010