BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol

Stable Identifier
R-HSA-373867
Type
Reaction
Species
Homo sapiens
Compartment
extracellular region, plasma membrane, cytosol
Synonyms
lactate + H+ [extracellular] <=> lactate + H+ [cytosol]
Locations in the PathwayBrowser
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Summation

The membrane-associated MCT:basigin complex mediates the reversible uptake of extracellular lactate and H+ (Wilson et al. 2005).

Literature References
PubMed ID Title Journal Year
15917240 Basigin (CD147) is the target for organomercurial inhibition of monocarboxylate transporter isoforms 1 and 4: the ancillary protein for the insensitive MCT2 is EMBIGIN (gp70)

Wilson, MC, Meredith, D, Fox, JE, Manoharan, C, Davies, AJ, Halestrap, AP

J Biol Chem 2005
Participants
Input
Output
Participant Of
hasEvent
Catalyst Activity
Catalyst Activity
Title
lactate transmembrane transporter activity of BSG:MCTs [plasma membrane]
Physical Entity
BSG:MCTs [plasma membrane]
Activity
lactate transmembrane transporter activity (0015129)
Orthologous Events
lactate + H+ [extracellular] <=> lactate + H+ [cytosol] (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Bos taurus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Canis familiaris)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Danio rerio)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Gallus gallus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Mus musculus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Rattus norvegicus)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Sus scrofa)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Taeniopygia guttata)
BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2008-07-17)