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APLNR [plasma membrane]
Stable Identifier
R-HSA-374259
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Apelin receptor, APJ_HUMAN, AGTRL1
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Apelin receptor binds to apelin (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
APLNR [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P35414 APLNR
Gene Names
APLNR, AGTRL1, APJ
Chain
chain:1-380
Reference Genes
BioGPS Gene:187 APLNR
COSMIC (genes):APLNR APLNR
CTD Gene:187 APLNR
dbSNP Gene:187 APLNR
ENSEMBL:ENSG00000134817 APLNR
ENSEMBL_homo_sapiens_GENE:ENSG00000134817.12 APLNR
HGNC:339 APLNR
KEGG Gene (Homo sapiens):187 APLNR
Monarch:187 APLNR
NCBI Gene:187 APLNR
OMIM:600052 APLNR
UCSC:P35414 APLNR
Reference Transcript
RefSeq:NM_005161.4 APLNR
Other Identifiers
11722792_a_at
11754410_s_at
16738400
184_at
187
213592_3p_at
213592_PM_at
213592_at
3373639
3373640
3373641
3373642
3373643
3373644
3373645
3373646
3373647
3373648
55636_at
7948167
A_23_P318860
GE60119
GE80348
GO:0001525
GO:0001568
GO:0001570
GO:0001944
GO:0001947
GO:0003171
GO:0003272
GO:0004930
GO:0005515
GO:0005886
GO:0007165
GO:0007186
GO:0007369
GO:0007507
GO:0007512
GO:0010468
GO:0010629
GO:0016020
GO:0023052
GO:0030154
GO:0034330
GO:0035886
GO:0035904
GO:0036211
GO:0038023
GO:0043951
GO:0045766
GO:0048856
GO:0050878
GO:0051281
GO:0055065
GO:0055085
GO:0060089
GO:0060182
GO:0060183
GO:0060412
GO:0060841
GO:0060976
GO:1903589
GO:1903596
GO:1904325
HMNXSV003051153
Hs.9305.0.S2_3p_at
Hs.9305.0.S2_3p_s_at
ILMN_1700183
PH_hs_0020741
TC11001786.hg
TC11003162.hg
U03642_at
Participates
as an input of
Apelin receptor binds to apelin (Homo sapiens)
as a component of
APLNR:Apelin peptides [plasma membrane] (Homo sapiens)
Inferred To
aplnrb [plasma membrane]
(Danio rerio)
Aplnr [plasma membrane]
(Mus musculus)
Aplnr [plasma membrane]
(Rattus norvegicus)
APLNR1 [plasma membrane]
(Gallus gallus)
Homologues of APLNR [plasma membrane]
(Danio rerio)
APLNR [plasma membrane]
(Bos taurus)
APLNR [plasma membrane]
(Sus scrofa)
aplnr3 [plasma membrane]
(Danio rerio)
aplnra [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_005152.1
Guide to Pharmacology - Targets
36
OpenTargets
ENSG00000134817
ZINC - Substances
APJ_HUMAN
ZINC target
P35414
PRO
P35414
PDB
2LOT
,
7W0N
,
2LOW
,
7W0L
,
2LOV
,
5VBL
,
7SUS
,
2LOU
,
7W0M
,
7W0O
,
6KNM
,
7W0P
GeneCards
P35414
HPA
ENSG00000134817-APLNR
Ensembl
ENST00000606794
,
ENSG00000134817
,
ENSP00000475344
,
ENSP00000257254
,
ENST00000257254
Pharos - Targets
P35414
ZINC - Predictions - Purchasable
APJ_HUMAN
HMDB Protein
HMDBP12615
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30556 AGTR1
2
AGTR1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869071)
AGTR1 [plasma membrane]
(R-HSA-374247)
0.713
14
UniProt:P41145 OPRK1
1
OPRK1 [plasma membrane]
(R-HSA-374286)
0.654
4
UniProt:P29033 GJB2
3
GJB2 [plasma membrane]
(R-HSA-53211)
GJB2 [endoplasmic reticulum membrane]
(R-HSA-1629779)
GJB2 [endoplasmic reticulum-Golgi intermediate compartment]
(R-HSA-190614)
0.556
3
UniProt:O43613 HCRTR1
1
HCRTR1 [plasma membrane]
(R-HSA-389490)
0.556
6
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.463
3
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