Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
OPRK1 [plasma membrane]
Stable Identifier
R-HSA-374286
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Kappa-type opioid receptor, OPRK_HUMAN
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by MECP2 (Homo sapiens)
MECP2 regulates neuronal receptors and channels (Homo sapiens)
OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (i) signalling events (Homo sapiens)
Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
GPCR ligand binding (Homo sapiens)
Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
Peptide ligand-binding receptors (Homo sapiens)
Opioid receptors bind opioid peptides (Homo sapiens)
Opioid receptor:opioid ligand [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
Opioid receptors [plasma membrane] (Homo sapiens)
OPRK1 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P41145 OPRK1
Gene Names
OPRK1, OPRK
Chain
chain:1-380
Reference Genes
BioGPS Gene:4986 OPRK1
COSMIC (genes):OPRK1 OPRK1
CTD Gene:4986 OPRK1
dbSNP Gene:4986 OPRK1
ENSEMBL:ENSG00000082556 OPRK1
ENSEMBL_homo_sapiens_GENE:ENSG00000082556.14 OPRK1
HGNC:8154 OPRK1
KEGG Gene (Homo sapiens):4986 OPRK1
Monarch:4986 OPRK1
NCBI Gene:4986 OPRK1
OMIM:165196 OPRK1
UCSC:P41145 OPRK1
Reference Transcript
RefSeq:NM_001282904.1 OPRK1
RefSeq:NM_000912.4 OPRK1
RefSeq:NM_001318497.1 OPRK1
Other Identifiers
11730673_at
11752950_a_at
11763621_a_at
11763814_a_at
17077171
207553_PM_at
207553_at
229944_PM_at
229944_at
3135348
3135349
3135350
3135351
3135352
3135353
3135354
3135355
3135356
3135357
3135358
3135359
3135360
3135361
3135362
3135363
35024_at
4986
58176_at
8150785
89039_at
A_23_P169061
A_32_P33576
GE479569
GE895359
GO:0002376
GO:0004930
GO:0004985
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0005886
GO:0006955
GO:0007165
GO:0007186
GO:0007193
GO:0007200
GO:0007218
GO:0007268
GO:0007600
GO:0007610
GO:0007626
GO:0016020
GO:0019233
GO:0022414
GO:0022600
GO:0023052
GO:0030425
GO:0030672
GO:0031410
GO:0031635
GO:0032868
GO:0033603
GO:0033612
GO:0033685
GO:0038003
GO:0038048
GO:0042220
GO:0042711
GO:0042734
GO:0042755
GO:0042923
GO:0043005
GO:0043025
GO:0043204
GO:0043226
GO:0043627
GO:0043679
GO:0044849
GO:0045211
GO:0045471
GO:0046877
GO:0048148
GO:0050877
GO:0050886
GO:0050951
GO:0051607
GO:0055085
GO:0060089
GO:0071222
GO:0071333
GO:0098542
GO:1900745
GO:1901381
GO:1903937
GO:1904000
GO:1990708
HMNXSV003053464
Hs.106795.0.S1_3p_at
ILMN_1714782
L37362_at
PH_hs_0004984
PH_hs_0005940
TC08001212.hg
TC08002324.hg
g4505510_3p_at
p33895
Participates
as an output of
OPRK1 gene expression is stimulated by MECP2 (Homo sapiens)
as a member of
Opioid receptors [plasma membrane] (Homo sapiens)
Inferred To
npr-16 [plasma membrane]
(Caenorhabditis elegans)
OPRK1 [plasma membrane]
(Bos taurus)
OPRK1 [plasma membrane]
(Caenorhabditis elegans)
OPRK1 [plasma membrane]
(Canis familiaris)
OPRK1 [plasma membrane]
(Gallus gallus)
OPRK1 [plasma membrane]
(Sus scrofa)
npr-26 [plasma membrane]
(Caenorhabditis elegans)
Oprk1 [plasma membrane]
(Mus musculus)
Oprk1 [plasma membrane]
(Rattus norvegicus)
npr-24 [plasma membrane]
(Caenorhabditis elegans)
npr-28 [plasma membrane]
(Caenorhabditis elegans)
npr-18 [plasma membrane]
(Caenorhabditis elegans)
AstC-R1 [plasma membrane]
(Drosophila melanogaster)
Homologues of OPRK1 [plasma membrane]
(Caenorhabditis elegans)
Homologues of OPRK1 [plasma membrane]
(Drosophila melanogaster)
AstC-R2 [plasma membrane]
(Drosophila melanogaster)
npr-23 [plasma membrane]
(Caenorhabditis elegans)
Rh7 [plasma membrane]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001269833.1
,
NP_001305426.1
,
NP_000903.2
ZINC - World Drugs
OPRK_HUMAN
Guide to Pharmacology - Targets
318
OpenTargets
ENSG00000082556
ZINC - FDA approved
OPRK_HUMAN
ZINC - Substances
OPRK_HUMAN
ZINC - Biogenic
OPRK_HUMAN
ZINC target
P41145
PRO
P41145
PDB
8DZQ
,
6VI4
,
8DZR
,
7T11
,
8DZS
,
8DZP
,
7UL3
,
7UL2
,
7Y1F
,
7YIT
,
7UL5
,
8F7W
,
4DJH
,
6B73
,
7T10
ZINC - Investigational
OPRK_HUMAN
ZINC - Metabolites
OPRK_HUMAN
HPA
ENSG00000082556-OPRK1
GeneCards
P41145
Ensembl
ENSG00000082556
,
ENST00000524278
,
ENST00000520287
,
ENST00000265572
,
ENSP00000430923
,
ENSP00000429706
,
ENSP00000265572
Pharos - Targets
P41145
ZINC - Predictions - Purchasable
OPRK_HUMAN
Orphanet
25741
HMDB Protein
HMDBP07856
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35414 APLNR
1
APLNR [plasma membrane]
(R-HSA-374259)
0.654
4
UniProt:Q9H0R8 GABARAPL1
3
GABARAPL1 [autophagosome membrane]
(R-HSA-5683637)
GABARAPL1(1-117) [cytosol]
(R-HSA-5682659)
GABARAPL1 [cytosol]
(R-HSA-5671757)
0.633
5
UniProt:Q16617 NKG7
0.556
3
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text