Reactome | p-T567-EZR [cytosol]

p-T567-EZR [cytosol]

Stable Identifier

R-HSA-374559

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated Ezrin

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P15311 EZR

Gene Names

EZR, VIL2

Chain

chain:1-586

Reference Genes

BioGPS Gene:7430 EZR

COSMIC (genes):EZR EZR

CTD Gene:7430 EZR

dbSNP Gene:7430 EZR

ENSEMBL:ENSG00000092820 EZR

HGNC:12691 EZR

Monarch:7430 EZR

NCBI Gene:7430 EZR

OMIM:123900 EZR

UCSC:P15311 EZR

Reference Transcript

Other Identifiers

11742987_s_at

11742988_s_at

11742989_a_at

11742990_x_at

11749746_s_at

17025189

17025191

208621_PM_s_at

208621_s_at

208622_PM_s_at

208622_s_at

208623_PM_s_at

208623_s_at

217234_PM_s_at

217234_s_at

2634427

2981913

2981914

2981915

2981916

2981917

2981918

2981919

2981920

2981923

2981924

2981926

2981927

2981928

2981930

2981931

2981932

2981935

2981940

2981942

2981943

2981948

2981949

2981951

2981953

2981967

2981968

2981969

40103_at

7430

8130505

A_23_P19590

A_24_P290481

GE81271

GO:0000122

GO:0001650

GO:0001726

GO:0001772

GO:0001931

GO:0001951

GO:0003376

GO:0003723

GO:0003779

GO:0005515

GO:0005615

GO:0005737

GO:0005768

GO:0005815

GO:0005829

GO:0005856

GO:0005884

GO:0005886

GO:0005902

GO:0005903

GO:0005912

GO:0005925

GO:0005938

GO:0006355

GO:0007010

GO:0007155

GO:0007159

GO:0007163

GO:0008017

GO:0008092

GO:0008360

GO:0010628

GO:0010737

GO:0015629

GO:0016020

GO:0016192

GO:0016323

GO:0016324

GO:0019904

GO:0022600

GO:0022614

GO:0030033

GO:0030036

GO:0030175

GO:0030863

GO:0030953

GO:0031410

GO:0031503

GO:0031528

GO:0031623

GO:0031982

GO:0032532

GO:0032587

GO:0032703

GO:0032991

GO:0034236

GO:0034237

GO:0035088

GO:0036064

GO:0040018

GO:0042802

GO:0042995

GO:0043226

GO:0043622

GO:0044548

GO:0044853

GO:0045177

GO:0045296

GO:0045732

GO:0046847

GO:0048471

GO:0048856

GO:0050839

GO:0050860

GO:0051015

GO:0051017

GO:0051018

GO:0051117

GO:0051660

GO:0061028

GO:0070062

GO:0070373

GO:0071320

GO:0071944

GO:0072659

GO:0072697

GO:0097718

GO:0098974

GO:1902115

GO:1902896

GO:1902966

GO:1903078

GO:1903753

GO:2000643

HMNXSV003005896

HMNXSV003008544

HMNXSV003047824

Hs.155191.0.S1_3p_a_at

Hs.155191.0.S2_3p_a_at

Hs.155191.1.S1_3p_a_at

ILMN_1795937

PH_hs_0024623

TC06002264.hg

TC06002265.hg

X51521_at

g340216_3p_a_at

Participates

as a component of

Other forms of this molecule

p-Y146,Y354-EZR [cytosol]

EZR [cytosol]

Inferred To

phospho-Moe [cytosol] (Drosophila melanogaster)

phospho-Ezr [cytosol] (Mus musculus)

phospho-Ezr [cytosol] (Rattus norvegicus)

phospho-EZR [cytosol] (Bos taurus)

phospho-EZR [cytosol] (Sus scrofa)

phospho-p-T567-EZR [cytosol] (Caenorhabditis elegans)

phospho-p-T567-EZR [cytosol] (Canis familiaris)

phospho-p-T567-EZR [cytosol] (Danio rerio)

phospho-p-T567-EZR [cytosol] (Gallus gallus)

phospho-p-T567-EZR [cytosol] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-threonine at 567

Coordinate

567

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Cross References

ENSEMBL

ENSP00000356042, ENSP00000338934, ENST00000367075, ENST00000337147

OpenTargets

ENSG00000092820

HPA

ENSG00000092820-EZR

ZINC - Substances

EZRI_HUMAN

ZINC target

P15311

PRO

P15311

Pharos - Targets

P15311

Orphanet

EZR

GlyGen

P15311

PDB

4RM9, 7T1K, 7T1L, 4RM8, 1NI2, 4RMA

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O14745 NHRF1			0.852	7
UniProt:P35241 RDX	2	p-T564-RDX [cytosol] (R-HSA-9662922) RDX [cytosol] (R-HSA-437348)	0.813	10
UniProt:P15311 EZR	3	p-Y146,Y354-EZR [cytosol] (R-HSA-374572) p-T567-EZR [cytosol] (R-HSA-374559) EZR [cytosol] (R-HSA-9020826)	0.783	8
UniProt:P26038 MSN	4	MSN [cytosol] (R-HSA-437350) MSN(2-448)-ALK(1064-1620) fusion [cytosol] (R-HSA-9711966) MSN(2-448)-p-7Y-ALK(1064-1620) fusion [cytosol] (R-HSA-9711971) p-T558-MSN [cytosol] (R-HSA-9663005)	0.745	10
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.745	22
UniProt:Q8IVT2 MISP			0.742	6
UniProt:P07332 FES	1	FES [cytosol] (R-HSA-396937)	0.678	8
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.653	3
UniProt:P26447 S10A4			0.611	3
UniProt:Q8IZE3 PACE1			0.608	5
UniProt:P55011 SLC12A2	1	SLC12A2 [plasma membrane] (R-HSA-426146)	0.589	3
UniProt:P23508 CRCM			0.589	2
UniProt:Q14457 BECN1	4	BECN1 [cytosol] (R-HSA-1632841) p-S15-BECN1 [cytosol] (R-HSA-5682391) ISG15-K-BECN1 [cytosol] (R-HSA-9853030) K63polyUb-BECN1 [cytosol] (R-HSA-6782989)	0.556	3
UniProt:Q8WU43 CB015			0.556	3
UniProt:Q8N108-16 MIER1			0.556	3
UniProt:Q8WTV1 THAP3			0.556	3
UniProt:Q15599 NHRF2			0.547	2
UniProt:Q8IZU9 KIRREL3	1	KIRREL3 [plasma membrane] (R-HSA-451428)	0.544	5
UniProt:P29034 S10A2			0.544	2
UniProt:P53779 MAPK10	3	p-T221,Y223-MAPK10 [nucleoplasm] (R-HSA-450311) p-T221,Y223-MAPK10 [cytosol] (R-HSA-450214) MAPK10 [cytosol] (R-HSA-450352)	0.527	2
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial inner membrane] (R-HSA-5368256) MRPL12 [mitochondrial matrix] (R-HSA-9839674)	0.527	3
UniProt:Q00987 MDM2	11	p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) MDM2 [endocytic vesicle membrane] (R-HSA-416849) MDM2 [plasma membrane] (R-HSA-416843) PolyUb,p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6795669) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) PolyUb-MDM2 [nucleoplasm] (R-HSA-6782472)	0.524	3
UniProt:Q63155 Dcc	5	DCC [plasma membrane] (R-RNO-421662) phospho-Dcc [plasma membrane] (R-RNO-374552) Dcc [cytosol] (R-RNO-373629) Dcc [plasma membrane] (R-RNO-197560) Dcc [plasma membrane] (R-RNO-373627)	0.524	3
UniProt:Q9BXI6 TBC1D10A	2	TBC1D10A [cytosol] (R-HSA-8854139) TBC1D10A [microvillus] (R-HSA-8854143)	0.491	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.483	10
UniProt:O43318 MAP3K7	10	PolyUb-MAP3K7 [cytosol] (R-HSA-6782968) MAP3K7 [plasma membrane] (R-HSA-9012677) p-T187-MAP3K7 [cytosol] (R-HSA-206014) K63polyUb-34,158-TAK1 [cytosol] (R-HSA-5607643) K63polyUb-34,158-p-T178,184,187,S192-TAK1 [cytosol] (R-HSA-5607649) p-MAP3K7 [cytosol] (R-HSA-168163) MAP3K7 [endosome membrane] (R-HSA-450315) p-T184,T187-MAP3K7 [endosome membrane] (R-HSA-450332) MAP3K7 [cytosol] (R-HSA-168156) p-T184,T187-MAP3K7 [cytosol] (R-HSA-202527)	0.483	2
UniProt:P11274 BCR	4	BCR [cytosol] (R-HSA-195200) BCR(1-584)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604524) p-Y177-BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839041) BCR(1-584)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1838979)	0.483	3
UniProt:P52565 ARHGDIA	1	ARHGDIA [cytosol] (R-HSA-194478)	0.463	2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE			0.462	2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE			0.462	2

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