Reactome | SIAH1 [cytosol]

SIAH1 [cytosol]

Stable Identifier

R-HSA-374563

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase SIAH1, SIAH1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P61086 UBE2K

Expand all

External Reference Information

External Reference

UniProt:Q8IUQ4 SIAH1

Gene Names

SIAH1, HUMSIAH

Chain

chain:1-282

Reference Genes

BioGPS Gene:6477 SIAH1

COSMIC (genes):SIAH1 SIAH1

CTD Gene:6477 SIAH1

dbSNP Gene:6477 SIAH1

ENSEMBL:ENSG00000196470 SIAH1

ENSEMBL_homo_sapiens_GENE:ENSG00000196470.12 SIAH1

HGNC:10857 SIAH1

KEGG Gene (Homo sapiens):6477 SIAH1

Monarch:6477 SIAH1

NCBI Gene:6477 SIAH1

OMIM:602212 SIAH1

UCSC:Q8IUQ4 SIAH1

Reference Transcript

Other Identifiers

11739661_a_at

11739662_x_at

11744928_x_at

11749340_s_at

11752177_a_at

16826356

202980_PM_s_at

202980_s_at

202981_PM_x_at

202981_x_at

232365_3p_at

232365_PM_at

232365_at

32160_at

3690551

3690552

3690553

3690554

3690555

3690556

3690557

3690558

3690559

3690560

3690561

3690562

3690563

3690566

3690580

3690581

3690582

3690583

6477

8001306

87291_at

A_23_P106798

A_33_P3270509

GE81225

GO:0003824

GO:0004842

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0006511

GO:0006915

GO:0007049

GO:0007275

GO:0007283

GO:0007399

GO:0007411

GO:0008270

GO:0009653

GO:0012501

GO:0016567

GO:0016740

GO:0022414

GO:0023052

GO:0030154

GO:0030163

GO:0030877

GO:0031624

GO:0036211

GO:0042802

GO:0043065

GO:0043161

GO:0043226

GO:0046872

GO:0048856

GO:0051402

GO:0060070

GO:0061630

GO:0140096

GO:1990000

GO:2001244

HMNXSV003030611

HMNXSV003050481

HMNXSV003051058

Hs.188990.0.S1_3p_x_at

Hs.295923.0.S1_3p_a_at

ILMN_1661161

ILMN_1711627

ILMN_1888224

ILMN_2279413

ILMN_2380566

PH_hs_0015319

TC16001095.hg

g4506946_3p_at

g4506946_3p_x_at

p6003

Participates

as a component of

as an input of

DCC interaction with SIAH1 (Homo sapiens)

as a member of

as an output of

Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)

Inferred To

SIAH1 [cytosol] (Bos taurus)

SIAH1 [cytosol] (Caenorhabditis elegans)

SIAH1 [cytosol] (Canis familiaris)

SIAH1 [cytosol] (Danio rerio)

SIAH1 [cytosol] (Drosophila melanogaster)

SIAH1 [cytosol] (Gallus gallus)

SIAH1 [cytosol] (Mus musculus)

SIAH1 [cytosol] (Rattus norvegicus)

SIAH1 [cytosol] (Sus scrofa)

siah1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011521581.1, NP_003022.3, XP_006721309.1, NP_001006611.1

OpenTargets

ENSG00000196470

HPA

ENSG00000196470-SIAH1

GeneCards

Q8IUQ4

Ensembl

ENSP00000378214, ENST00000380006, ENSP00000369343, ENSP00000349156, ENST00000568007, ENST00000394725, ENST00000356721, ENSP00000456421, ENSG00000196470

PRO

Q8IUQ4

Pharos - Targets

Q8IUQ4

HMDB Protein

HMDBP09307

PDB

4I7D, 5WZZ, 4I7B, 2A25, 8HEO, 4X3G, 4C9Z, 4CA1, 4I7C

Interactors (94)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.742	7
UniProt:Q8IXK0 PHC2	1	PHC2 [nucleoplasm] (R-HSA-389112)	0.742	5
UniProt:Q8IUQ4 SIAH1	1	SIAH1 [cytosol] (R-HSA-374563)	0.668	3
UniProt:P61086 UBE2K	2	UBE2K [cytosol] (R-HSA-934631) Ub-C92-UBE2K [cytosol] (R-HSA-8864200)	0.666	4
UniProt:P29692 EEF1D	1	EEF1D [cytosol] (R-HSA-156914)	0.666	4
UniProt:Q9HB71 CYBP			0.637	3
UniProt:Q64693 OBF1			0.626	5
UniProt:P35372 OPRM1	1	OPRM1 [plasma membrane] (R-HSA-60951)	0.581	4
UniProt:P69713 X			0.571	4
UniProt:P86479 PR20C			0.556	5
UniProt:Q8WW36 ZCH13			0.556	3
UniProt:P05111 INHA	1	INHA [extracellular region] (R-HSA-1449702)	0.556	3
UniProt:Q8WTR4 GDPD5	1	GDPD5 [endoplasmic reticulum membrane] (R-HSA-6814136)	0.556	3
UniProt:Q86TG7 PEG10			0.556	3
UniProt:Q59GP6 Q59GP6			0.556	3
UniProt:Q9C029 TRIM7			0.556	3
UniProt:Q9BQ24 ZFY21			0.556	3
UniProt:Q9BW62 KATL1			0.556	3
UniProt:Q8TBK6 ZCH10			0.556	3
IntAct:EBI-10261370 6157			0.556	3
UniProt:Q8N619 Q8N619			0.556	3
UniProt:Q96B01 RAD51AP1	1	RAD51AP1 [nucleoplasm] (R-HSA-5685301)	0.556	3
UniProt:ZNF671 A0A0C4DH15			0.556	3
UniProt:Q8TAN2 Q8TAN2			0.556	3
UniProt:Q9UQR1 ZN148			0.556	3
UniProt:Q86YD7 F90A1			0.556	3
UniProt:Q9NRN7 AASDHPPT	1	AASDHPPT [cytosol] (R-HSA-199235)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q92692 NECTIN2	1	PVRL2 [plasma membrane] (R-HSA-419006)	0.556	3
UniProt:Q13394 MB211			0.556	3
UniProt:Q14088 RAB33A	3	RAB33A [Golgi membrane] (R-HSA-8854592) GGC-RAB33A [cytosol] (R-HSA-8873981) RAB33A [cytosol] (R-HSA-8873704)	0.556	3
UniProt:Q9Y4B4 ARIP4			0.556	3
UniProt:Q53H82 LACB2			0.556	3
UniProt:P40121 CAPG			0.556	3
UniProt:Q9UHB7-2 AFF4			0.556	5
UniProt:Q9H6R4-4 NOL6			0.556	3
UniProt:Q9BTV4 TMM43			0.556	3
UniProt:Q8WWY3 PRPF31	1	PRPF31 [nucleoplasm] (R-HSA-6806772)	0.556	3
UniProt:Q8NEY3 SPAT4			0.556	3
UniProt:Q6FIE9 Q6FIE9			0.556	3
UniProt:O43581 SYT7	1	SYT7 [synaptic vesicle membrane] (R-HSA-6789228)	0.556	3
UniProt:Q86WX3 RPS19BP1	1	RPS19BP1 [nucleoplasm] (R-HSA-3371427)	0.556	3
UniProt:Q96HA8 NTAQ1			0.556	3
UniProt:O14645 IDLC			0.556	3
UniProt:Q9Y5T4 DJC15			0.556	3
UniProt:Q8N2X6 EXAS1			0.556	3
UniProt:O60336 MABP1			0.556	3
UniProt:O95045 UPP2	1	UPP2 [cytosol] (R-HSA-977410)	0.556	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
UniProt:Q8IZA0 K319L			0.556	3
UniProt:P41182 BCL6	1	BCL6 [nucleoplasm] (R-HSA-5223066)	0.556	3
UniProt:P11216 PYGB	4	PXLP-PYGB [extracellular region] (R-HSA-6801536) PXLP-PYGB [azurophil granule lumen] (R-HSA-6799164) PXLP-p-S15-PYGB [cytosol] (R-HSA-71868) PXLP-PYGB [cytosol] (R-HSA-71862)	0.556	3
UniProt:P78508 KCNJ10	1	KCNJ10 [plasma membrane] (R-HSA-975290)	0.556	3
UniProt:P49427 CDC34	4	Ub-C93-CDC34 [cytosol] (R-HSA-8864170) Ub-C93-CDC34 [nucleoplasm] (R-HSA-8864204) CDC34 [nucleoplasm] (R-HSA-8852125) CDC34 [cytosol] (R-HSA-947621)	0.556	3
UniProt:P29972 AQP1	1	AQP1 [plasma membrane] (R-HSA-431700)	0.556	3
UniProt:Q70IA8 MOB3C			0.556	3
UniProt:Q9UJV9 DDX41	4	DDX41 [nucleoplasm] (R-HSA-9769601) DDX41 [cytosol] (R-HSA-3134807) K48polyUb-DDX41 [cytosol] (R-HSA-3134942) K48polyUb-DDX41 [cytosol] (R-HSA-3134941)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:Q13625-3 TP53BP2			0.556	3
UniProt:O60333 KIF1B	1	KIF1B [cytosol] (R-HSA-8849378)	0.556	3
UniProt:P08237 PFKM	1	PFKM [cytosol] (R-HSA-70460)	0.556	3
UniProt:P62805 H4C1	17	polySUMO3-HIST1H4 [nucleoplasm] (R-HSA-4570531) monoSUMO1-HIST1H4 [nucleoplasm] (R-HSA-4570518) 4xAcK-HIST1H4A [nucleoplasm] (R-HSA-427390) AcK5,12-HIST1H4A [nucleoplasm] (R-HSA-212078) AcK13-HIST1H4 [nucleoplasm] (R-HSA-4568744) Me2aR4-HIST1H4 [nucleoplasm] (R-HSA-5229015) Me2sR4-HIST1H4 [nucleoplasm] (R-HSA-4754243) MeR4-HIST1H4 [nucleoplasm] (R-HSA-4754240) Me3K21-HIST1H4 [nucleoplasm] (R-HSA-5651656) HIST1H4A [extracellular region] (R-HSA-977569) AcK17-HIST1H4 [nucleoplasm] (R-HSA-427469) AcK6-HIST1H4 [nucleoplasm] (R-HSA-4568748) AcK9-HIST1H4 [nucleoplasm] (R-HSA-4568758) MeK21-HIST1H4 [nucleoplasm] (R-HSA-5423110) AcK-HIST1H4 [nucleoplasm] (R-HSA-3451124) Me2K21-HIST1H4 [nucleoplasm] (R-HSA-5651652) HIST1H4 [nucleoplasm] (R-HSA-181902)	0.556	3
UniProt:Q9H0A9 SPC1L			0.556	3
UniProt:Q9UJX2 CDC23	2	CDC23 [cytosol] (R-HSA-174137) CDC23 [nucleoplasm] (R-HSA-174228)	0.556	3
UniProt:Q96DC9 OTUB2	2	OTUB2 [cytosol] (R-HSA-933410) OTUB2 [nucleoplasm] (R-HSA-6783260)	0.556	3
UniProt:Q9BVG8 KIFC3			0.556	3
UniProt:Q9NU19 TB22B			0.556	3
UniProt:Q8WUK0 DUSP23	1	PTPMT1 [mitochondrial inner membrane] (R-HSA-3446802)	0.556	3
UniProt:Q96KM6 ZNF512B	1	ZNF512B [cytosol] (R-HSA-9715175)	0.556	3
UniProt:Q9NVL8 FAME			0.556	3
UniProt:A2RRL9 A2RRL9			0.556	3
UniProt:P36406 TRI23			0.556	3
UniProt:Q2TAL8 QRIC1			0.556	3
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:Q01543 FLI1	1	FLI1 [nucleoplasm] (R-HSA-9616216)	0.556	3
UniProt:P20591 MX1	1	MX1 [cytosol] (R-HSA-947489)	0.556	3
UniProt:Q9H0B3 IQCN			0.556	3
UniProt:Q7Z3E5-2 ARMC9			0.556	3
UniProt:Q8TAM4 Q8TAM4			0.556	3
UniProt:P53778 MAPK12	3	MAPK12 [cytosol] (R-HSA-171025) p-T183,Y185-MAPK12 [cytosol] (R-HSA-171021) MAPK12 [nucleoplasm] (R-HSA-448833)	0.556	3
UniProt:Q96B01-2 RAD51AP1			0.556	3
UniProt:Q9HA38 ZMAT3			0.556	3
UniProt:Q9UHB7 AFF4	1	AFF4 [nucleoplasm] (R-HSA-8932788)	0.556	5
UniProt:Q9UBK9 UXT	1	UXT [nucleoplasm] (R-HSA-9007484)	0.556	3
UniProt:P61077 UBE2D3	3	UBE2D3 [nucleoplasm] (R-HSA-205341) UBE2D3 [cytosol] (R-HSA-934630) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191)	0.553	2
UniProt:P54259 ATN1	1	ATN1 [nucleoplasm] (R-HSA-6807083)	0.553	2
UniProt:P62837 UBE2D2	4	Ub-C85-UBE2D2 [nucleoplasm] (R-HSA-8864153) UBE2D2 [nucleoplasm] (R-HSA-8852067) UBE2D2 [cytosol] (R-HSA-934628) Ub-C85-UBE2D2 [cytosol] (R-HSA-8864214)	0.553	2
UniProt:Q69ZI1	1	Sh3rf1 [cytosol] (R-MMU-5688968)	0.544	5
UniProt:Q99836 MYD88	8	MyD88 R196C [cytosol] (R-HSA-5602329) MyD88 E52del [cytosol] (R-HSA-5602451) MyD88 L93P [cytosol] (R-HSA-5602612) MyD88 S34Y [cytosol] (R-HSA-5602521) MyD88 E65del [cytosol] (R-HSA-5602598) MYD88 [endosome membrane] (R-HSA-975123) MYD88 [plasma membrane] (R-HSA-937017) MYD88 [cytosol] (R-HSA-166059)	0.543	3
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.524	3
UniProt:O15265 ATXN7	2	ATXN7 [cytosol] (R-HSA-201591) ATXN7 [nucleoplasm] (R-HSA-8869458)	0.508	2
UniProt:Q15599 NHRF2			0.508	2
UniProt:Q16633 OBF1			0.508	2

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