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SIAH1 [cytosol]
Stable Identifier
R-HSA-374563
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase SIAH1, SIAH1_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q99836 MYD88
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Netrin-1 signaling (Homo sapiens)
DCC interaction with SIAH1 (Homo sapiens)
SIAH1 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Amyloid fiber formation (Homo sapiens)
Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)
SIAH1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q8IUQ4 SIAH1
Gene Names
SIAH1, HUMSIAH
Chain
chain:1-282
Reference Genes
BioGPS Gene:6477 SIAH1
COSMIC (genes):SIAH1 SIAH1
CTD Gene:6477 SIAH1
dbSNP Gene:6477 SIAH1
ENSEMBL:ENSG00000196470 SIAH1
ENSEMBL_homo_sapiens_GENE:ENSG00000196470.12 SIAH1
HGNC:10857 SIAH1
KEGG Gene (Homo sapiens):6477 SIAH1
Monarch:6477 SIAH1
NCBI Gene:6477 SIAH1
OMIM:602212 SIAH1
UCSC:Q8IUQ4 SIAH1
Reference Transcript
RefSeq:NM_003031.3 SIAH1
RefSeq:NM_001006610.1 SIAH1
RefSeq:XM_011523279.1 SIAH1
RefSeq:XM_006721246.1 SIAH1
Other Identifiers
11739661_a_at
11739662_x_at
11744928_x_at
11749340_s_at
11752177_a_at
16826356
202980_PM_s_at
202980_s_at
202981_PM_x_at
202981_x_at
232365_3p_at
232365_PM_at
232365_at
32160_at
3690551
3690552
3690553
3690554
3690555
3690556
3690557
3690558
3690559
3690560
3690561
3690562
3690563
3690566
3690580
3690581
3690582
3690583
6477
8001306
87291_at
A_23_P106798
A_33_P3270509
GE81225
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005737
GO:0005829
GO:0006511
GO:0006915
GO:0007049
GO:0007275
GO:0007283
GO:0007399
GO:0007411
GO:0008270
GO:0009653
GO:0012501
GO:0016567
GO:0016740
GO:0022414
GO:0023052
GO:0030154
GO:0030163
GO:0030877
GO:0031624
GO:0036211
GO:0042802
GO:0043065
GO:0043161
GO:0043226
GO:0046872
GO:0048856
GO:0051402
GO:0060070
GO:0061630
GO:0140096
GO:1990000
GO:2001244
HMNXSV003030611
HMNXSV003050481
HMNXSV003051058
Hs.188990.0.S1_3p_x_at
Hs.295923.0.S1_3p_a_at
ILMN_1661161
ILMN_1711627
ILMN_1888224
ILMN_2279413
ILMN_2380566
PH_hs_0015319
TC16001095.hg
g4506946_3p_at
g4506946_3p_x_at
p6003
Participates
as a component of
NTN1:DCC:SIAH1 [plasma membrane] (Homo sapiens)
SIAH1:UBE2L6:Ub-SNCA [cytosol] (Homo sapiens)
as an input of
DCC interaction with SIAH1 (Homo sapiens)
as a member of
SIAH1, SIAH2 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
as an output of
Ub-SNCA dissociates from the conjugating enzyme (Homo sapiens)
Inferred To
SIAH1 [cytosol]
(Bos taurus)
SIAH1 [cytosol]
(Caenorhabditis elegans)
SIAH1 [cytosol]
(Canis familiaris)
SIAH1 [cytosol]
(Danio rerio)
SIAH1 [cytosol]
(Drosophila melanogaster)
SIAH1 [cytosol]
(Gallus gallus)
SIAH1 [cytosol]
(Mus musculus)
SIAH1 [cytosol]
(Rattus norvegicus)
SIAH1 [cytosol]
(Sus scrofa)
siah1 [cytosol]
(Xenopus tropicalis)
Cross References
RefSeq
XP_011521581.1
,
NP_003022.3
,
XP_006721309.1
,
NP_001006611.1
OpenTargets
ENSG00000196470
HPA
ENSG00000196470-SIAH1
GeneCards
Q8IUQ4
Ensembl
ENSP00000378214
,
ENST00000380006
,
ENSP00000369343
,
ENSP00000349156
,
ENST00000568007
,
ENST00000394725
,
ENST00000356721
,
ENSP00000456421
,
ENSG00000196470
PRO
Q8IUQ4
Pharos - Targets
Q8IUQ4
HMDB Protein
HMDBP09307
PDB
4I7D
,
5WZZ
,
4I7B
,
2A25
,
8HEO
,
4X3G
,
4C9Z
,
4CA1
,
4I7C
Interactors (94)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9UHX1 PUF60
1
PUF60 [nucleoplasm]
(R-HSA-8865910)
0.742
7
UniProt:Q8IXK0 PHC2
1
PHC2 [nucleoplasm]
(R-HSA-389112)
0.742
5
UniProt:Q8IUQ4 SIAH1
1
SIAH1 [cytosol]
(R-HSA-374563)
0.668
3
UniProt:P61086 UBE2K
2
UBE2K [cytosol]
(R-HSA-934631)
Ub-C92-UBE2K [cytosol]
(R-HSA-8864200)
0.666
4
UniProt:P29692 EEF1D
1
EEF1D [cytosol]
(R-HSA-156914)
0.666
4
UniProt:Q9HB71 CYBP
0.637
3
UniProt:Q64693 OBF1
0.626
5
UniProt:P35372 OPRM1
1
OPRM1 [plasma membrane]
(R-HSA-60951)
0.581
4
UniProt:P69713 X
0.571
4
UniProt:P86479 PR20C
0.556
5
UniProt:Q8WW36 ZCH13
0.556
3
UniProt:P05111 INHA
1
INHA [extracellular region]
(R-HSA-1449702)
0.556
3
UniProt:Q8WTR4 GDPD5
1
GDPD5 [endoplasmic reticulum membrane]
(R-HSA-6814136)
0.556
3
UniProt:Q86TG7 PEG10
0.556
3
UniProt:Q59GP6 Q59GP6
0.556
3
UniProt:Q9C029 TRIM7
0.556
3
UniProt:Q9BQ24 ZFY21
0.556
3
UniProt:Q9BW62 KATL1
0.556
3
UniProt:Q8TBK6 ZCH10
0.556
3
IntAct:EBI-10261370 6157
0.556
3
UniProt:Q8N619 Q8N619
0.556
3
UniProt:Q96B01 RAD51AP1
1
RAD51AP1 [nucleoplasm]
(R-HSA-5685301)
0.556
3
UniProt:ZNF671 A0A0C4DH15
0.556
3
UniProt:Q8TAN2 Q8TAN2
0.556
3
UniProt:Q9UQR1 ZN148
0.556
3
UniProt:Q86YD7 F90A1
0.556
3
UniProt:Q9NRN7 AASDHPPT
1
AASDHPPT [cytosol]
(R-HSA-199235)
0.556
3
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.556
3
UniProt:Q92692 NECTIN2
1
PVRL2 [plasma membrane]
(R-HSA-419006)
0.556
3
UniProt:Q13394 MB211
0.556
3
UniProt:Q14088 RAB33A
3
RAB33A [Golgi membrane]
(R-HSA-8854592)
GGC-RAB33A [cytosol]
(R-HSA-8873981)
RAB33A [cytosol]
(R-HSA-8873704)
0.556
3
UniProt:Q9Y4B4 ARIP4
0.556
3
UniProt:Q53H82 LACB2
0.556
3
UniProt:P40121 CAPG
0.556
3
UniProt:Q9UHB7-2 AFF4
0.556
5
UniProt:Q9H6R4-4 NOL6
0.556
3
UniProt:Q9BTV4 TMM43
0.556
3
UniProt:Q8WWY3 PRPF31
1
PRPF31 [nucleoplasm]
(R-HSA-6806772)
0.556
3
UniProt:Q8NEY3 SPAT4
0.556
3
UniProt:Q6FIE9 Q6FIE9
0.556
3
UniProt:O43581 SYT7
1
SYT7 [synaptic vesicle membrane]
(R-HSA-6789228)
0.556
3
UniProt:Q86WX3 RPS19BP1
1
RPS19BP1 [nucleoplasm]
(R-HSA-3371427)
0.556
3
UniProt:Q96HA8 NTAQ1
0.556
3
UniProt:O14645 IDLC
0.556
3
UniProt:Q9Y5T4 DJC15
0.556
3
UniProt:Q8N2X6 EXAS1
0.556
3
UniProt:O60336 MABP1
0.556
3
UniProt:O95045 UPP2
1
UPP2 [cytosol]
(R-HSA-977410)
0.556
3
UniProt:Q9H3P2 NELFA
1
NELFA [nucleoplasm]
(R-HSA-112426)
0.556
3
UniProt:Q5T5P2-6 KIAA1217
0.556
3
UniProt:Q8IZA0 K319L
0.556
3
UniProt:P41182 BCL6
1
BCL6 [nucleoplasm]
(R-HSA-5223066)
0.556
3
UniProt:P11216 PYGB
4
PXLP-PYGB [extracellular region]
(R-HSA-6801536)
PXLP-PYGB [azurophil granule lumen]
(R-HSA-6799164)
PXLP-p-S15-PYGB [cytosol]
(R-HSA-71868)
PXLP-PYGB [cytosol]
(R-HSA-71862)
0.556
3
UniProt:P78508 KCNJ10
1
KCNJ10 [plasma membrane]
(R-HSA-975290)
0.556
3
UniProt:P49427 CDC34
4
Ub-C93-CDC34 [cytosol]
(R-HSA-8864170)
Ub-C93-CDC34 [nucleoplasm]
(R-HSA-8864204)
CDC34 [nucleoplasm]
(R-HSA-8852125)
CDC34 [cytosol]
(R-HSA-947621)
0.556
3
UniProt:P29972 AQP1
1
AQP1 [plasma membrane]
(R-HSA-431700)
0.556
3
UniProt:Q70IA8 MOB3C
0.556
3
UniProt:Q9UJV9 DDX41
4
DDX41 [nucleoplasm]
(R-HSA-9769601)
DDX41 [cytosol]
(R-HSA-3134807)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134942)
K48polyUb-DDX41 [cytosol]
(R-HSA-3134941)
0.556
3
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.556
3
UniProt:Q13625-3 TP53BP2
0.556
3
UniProt:O60333 KIF1B
1
KIF1B [cytosol]
(R-HSA-8849378)
0.556
3
UniProt:P08237 PFKM
1
PFKM [cytosol]
(R-HSA-70460)
0.556
3
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.556
3
UniProt:Q9H0A9 SPC1L
0.556
3
UniProt:Q9UJX2 CDC23
2
CDC23 [cytosol]
(R-HSA-174137)
CDC23 [nucleoplasm]
(R-HSA-174228)
0.556
3
UniProt:Q96DC9 OTUB2
2
OTUB2 [cytosol]
(R-HSA-933410)
OTUB2 [nucleoplasm]
(R-HSA-6783260)
0.556
3
UniProt:Q9BVG8 KIFC3
0.556
3
UniProt:Q9NU19 TB22B
0.556
3
UniProt:Q8WUK0 DUSP23
1
PTPMT1 [mitochondrial inner membrane]
(R-HSA-3446802)
0.556
3
UniProt:Q96KM6 ZNF512B
1
ZNF512B [cytosol]
(R-HSA-9715175)
0.556
3
UniProt:Q9NVL8 FAME
0.556
3
UniProt:A2RRL9 A2RRL9
0.556
3
UniProt:P36406 TRI23
0.556
3
UniProt:Q2TAL8 QRIC1
0.556
3
UniProt:Q9H2K0 MTIF3
1
MTIF3 [mitochondrial matrix]
(R-HSA-5368284)
0.556
3
UniProt:Q01543 FLI1
1
FLI1 [nucleoplasm]
(R-HSA-9616216)
0.556
3
UniProt:P20591 MX1
1
MX1 [cytosol]
(R-HSA-947489)
0.556
3
UniProt:Q9H0B3 IQCN
0.556
3
UniProt:Q7Z3E5-2 ARMC9
0.556
3
UniProt:Q8TAM4 Q8TAM4
0.556
3
UniProt:P53778 MAPK12
3
MAPK12 [cytosol]
(R-HSA-171025)
p-T183,Y185-MAPK12 [cytosol]
(R-HSA-171021)
MAPK12 [nucleoplasm]
(R-HSA-448833)
0.556
3
UniProt:Q96B01-2 RAD51AP1
0.556
3
UniProt:Q9HA38 ZMAT3
0.556
3
UniProt:Q9UHB7 AFF4
1
AFF4 [nucleoplasm]
(R-HSA-8932788)
0.556
5
UniProt:Q9UBK9 UXT
1
UXT [nucleoplasm]
(R-HSA-9007484)
0.556
3
UniProt:P61077 UBE2D3
3
UBE2D3 [nucleoplasm]
(R-HSA-205341)
UBE2D3 [cytosol]
(R-HSA-934630)
Ub-C85-UBE2D3 [cytosol]
(R-HSA-8864191)
0.553
2
UniProt:P54259 ATN1
1
ATN1 [nucleoplasm]
(R-HSA-6807083)
0.553
2
UniProt:P62837 UBE2D2
4
Ub-C85-UBE2D2 [nucleoplasm]
(R-HSA-8864153)
UBE2D2 [nucleoplasm]
(R-HSA-8852067)
UBE2D2 [cytosol]
(R-HSA-934628)
Ub-C85-UBE2D2 [cytosol]
(R-HSA-8864214)
0.553
2
UniProt:Q69ZI1
1
Sh3rf1 [cytosol]
(R-MMU-5688968)
0.544
5
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.543
3
UniProt:P98170 XIAP
3
XIAP [nucleoplasm]
(R-HSA-3322366)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [cytosol]
(R-HSA-50849)
0.524
3
UniProt:O15265 ATXN7
2
ATXN7 [cytosol]
(R-HSA-201591)
ATXN7 [nucleoplasm]
(R-HSA-8869458)
0.508
2
UniProt:Q15599 NHRF2
0.508
2
UniProt:Q16633 OBF1
0.508
2
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