Reactome | DCC interaction with SIAH2

DCC interaction with SIAH2

Stable Identifier

R-HSA-374667

Type

Reaction [binding]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Siah-2 binds to the DCC protein and promote its proteolysis via the ubiquitin-proteasome pathway.

Literature References

PubMed ID	Title	Journal	Year
9858595	Siah-1 N-terminal RING domain is required for proteolysis function, and C-terminal sequences regulate oligomerization and binding to target proteins Hu, G, Fearon, ER	Mol Cell Biol	1999