Reactome: A Curated Pathway Database

L1 binds NRP1

Stable Identifier
R-HSA-374669
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1 interacts with neuropilin 1 (NP-1) through a conserved sequence (FASNKL) present with in the Ig1 domain of L1 and this association is required as a part of semaphorin 3A (Sema3A) receptor complex for axon guidance responses.
L1 interacts with NP-1 in cis to form a receptor complex that induces repulsive turning of the growth cone in response to Sema3A binding, whereas trans interaction of L1 with NP-1 switches Sema3A triggered repulsion to attraction.

Literature References
Participants
Participant Of
Orthologous Events