L1 and NCAM1 engaged in cis-interaction

Stable Identifier
R-HSA-374681
Type
Reaction
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
Summation

L1 and NCAM1 co-expressed on a single cell interact with each other via the fourth Ig domain of NCAM1 and the oligomannose type oligosaccharides carried by L1. This interaction has synergetic effects on L1-mediated cell aggregation and adhesion, a phenomenon referred to as 'assisted homophilic L1-L1 trans-binding'.

Literature References
PubMed ID Title Journal Year
8509458 The fourth immunoglobulin-like domain of NCAM contains a carbohydrate recognition domain for oligomannosidic glycans implicated in association with L1 and neurite outgrowth

Horstkorte, R, Schachner, M, Magyar, JP, Vorherr, T, Schmitz, B

J Cell Biol 1993
10611478 Homophilic NCAM interactions interfere with L1 stimulated neurite outgrowth

Kristiansen, LV, Marques, FA, Soroka, V, Ronn, LC, Kiselyov, V, Pedersen, N, Berezin, V, Bock, E

FEBS Lett 1999
2295682 The neural cell adhesion molecule N-CAM enhances L1-dependent cell-cell interactions

Kadmon, G, Kowitz, A, Altevogt, P, Schachner, M

J Cell Biol 1990
Participants
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Orthologous Events
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