Interaction of L1 with Neurocan

Stable Identifier
R-HSA-374683
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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L1CAM binds with high affinity to the proteoglycan neurocan. Neurocan binds to the first Ig domain of L1CAM through its sushi module and a chondroitin sulphate chain. This interaction interferes with the homophilic interaction of L1CAM and inhibits neuronal adhesion and neurite extension mediated by L1CAM.

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