Reactome | SST(103-116) [extracellular region]

SST(103-116) [extracellular region]

Stable Identifier

R-HSA-374738

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Somatostatin-14, SMS_HUMAN, SST

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by GPCR (Homo sapiens)
  - GPCR downstream signalling (Homo sapiens)
    - G alpha (i) signalling events (Homo sapiens)
      - Liganded Gi-activating GPCR acts as a GEF for Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
      - Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (inactive) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
      - The Ligand:GPCR:Gi complex dissociates (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi:Heterotrimeric G-protein Gi (active) [plasma membrane] (Homo sapiens)
        
        Ligand:GPCR complexes that activate Gi [plasma membrane] (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
  - GPCR ligand binding (Homo sapiens)
    - Class A/1 (Rhodopsin-like receptors) (Homo sapiens)
      - Peptide ligand-binding receptors (Homo sapiens)
        
        Somatostatin receptors bind somatostatin and cortistatin (Homo sapiens)
        
        Somatostatin receptor:somatostatin [plasma membrane] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)
        
        Somatostatin, cortistatin [extracellular region] (Homo sapiens)
        
        Somatostatin [extracellular region] (Homo sapiens)
        
        SST(103-116) [extracellular region] (Homo sapiens)

External Reference Information

External Reference

UniProt:P61278 SST

Gene Names

SST

Chain

signal peptide:1-24, propeptide:25-88, peptide:31-43, peptide:89-116, peptide:103-116

Reference Genes

BioGPS Gene:6750 SST

COSMIC (genes):SST SST

CTD Gene:6750 SST

dbSNP Gene:6750 SST

ENSEMBL:ENSG00000157005 SST

HGNC:11329 SST

KEGG:hsa:6750 SST

Monarch:6750 SST

NCBI Gene:6750 SST

OMIM:182450 SST

UCSC:P61278 SST

Reference Transcript

RefSeq:NM_001048.3 SST

Other Identifiers

11715481_a_at

1430_at

16962574

213921_PM_at

213921_at

2709751

2709752

2709755

2709756

37782_at

6750

8092682

A_23_P252817

GE61311

GO:0005179

GO:0005515

GO:0005576

GO:0005615

GO:0005829

GO:0006972

GO:0007166

GO:0007186

GO:0007267

GO:0007268

GO:0007584

GO:0007586

GO:0008285

GO:0008628

GO:0009410

GO:0010447

GO:0023052

GO:0030334

GO:0031410

GO:0038170

GO:0043025

GO:0043200

GO:0043226

GO:0048018

GO:0048545

GO:0098772

GO:0098982

GO:0098992

GO:0099072

HMNXSV003044144

Hs.12409.0.S1_3p_at

ILMN_1812824

J00306_at

PH_hs_0001176

TC03002094.hg

Participates

as a member of

Somatostatin [extracellular region] (Homo sapiens)

Other forms of this molecule

SST(89-116) [extracellular region]

Inferred To

Sst [extracellular region] (Rattus norvegicus)

sst1.1 [extracellular region] (Danio rerio)

Sst(103-116) [extracellular region] (Mus musculus)

sst.1 [extracellular region] (Xenopus tropicalis)

SST [extracellular region] (Bos taurus)

SST [extracellular region] (Canis familiaris)

SST [extracellular region] (Gallus gallus)

SST [extracellular region] (Sus scrofa)

Cross References

RefSeq

NP_001039.1

ENSEMBL

ENSP00000287641, ENST00000287641

OpenTargets

ENSG00000157005

HPA

ENSG00000157005-SST

PRO

P61278

Pharos - Targets

P61278

HMDB Protein

HMDBP01649

PDB

2MI1, 7Y27, 7T10, 7WIC, 7XMR, 7WJ5, 7XMS, 7XAT

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3