Reactome | PRNP [plasma membrane]

PRNP [plasma membrane]

Stable Identifier

R-HSA-375060

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Major prion protein, PRIO_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04156 PRNP

Gene Names

PRNP, ALTPRP, PRIP, PRP

Chain

signal peptide:1-22, chain:23-230, propeptide:231-253

Reference Genes

BioGPS Gene:5621 PRNP

COSMIC (genes):PRNP PRNP

CTD Gene:5621 PRNP

dbSNP Gene:5621 PRNP

ENSEMBL:ENSG00000171867 PRNP

HGNC:9449 PRNP

KEGG:hsa:5621 PRNP

Monarch:5621 PRNP

NCBI Gene:5621 PRNP

OMIM:176640 PRNP

UCSC:P04156 PRNP

Reference Transcript

Participates

as a component of

NCAM-1:Major prion protein [plasma membrane] (Homo sapiens)

as an input of

Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)

Other forms of this molecule

PRNP [cytosol]

Cross References

OpenTargets

ENSG00000171867

ENSEMBL

ENSP00000399376, ENSP00000411599, ENST00000424424, ENST00000457586, ENST00000430350, ENSP00000415284, ENST00000379440, ENSG00000171867, ENSP00000368752

ZINC - FDA approved

PRIO_HUMAN

ZINC - Substances

PRIO_HUMAN

ZINC - Biogenic

PRIO_HUMAN

ZINC target

P04156

PRO

P04156

GlyGen

P04156

PDB

6PQA, 2LV1, 3HES, 2LBG, 7RVJ, 5YJ5, 4N9O, 6DU9, 2OL9, 1FO7, 7UMQ, 1HJM, 3NHD, 4E1H, 7UN5, 6SV2, 2IV5, 2LSB, 2M8T, 3HAK, 2W9E, 1FKC, 2K1D, 3HAF, 7DWV, 1E1J, 2LEJ, 1E1W, 1E1U, 1QM2, 1QM0, 3HJ5, 3MD4, 7RVK, 3MD5, 3NVF, 3HER, 1E1S, 1E1P, 1OEH, 4KML, 1OEI, 5YJ4, 6SUZ, 1H0L, 5L6R, 4E1I, 7RL4, 1HJN, 3HJX, 3NHC, 6PQ5, 2IV4, 2LFT, 2KUN, 7FHQ, 2IV6, 6UUR, 1QLZ, 1QLX, 6LNI, 1E1G, 1I4M, 7RVE, 7RVC, 1QM3, 1QM1, 7RVL, 4DGI, 3HEQ

HPA

ENSG00000171867-PRNP

GeneCards

PRNP

Pharos - Targets

P04156

Orphanet

PRNP

ZINC - Predictions - Purchasable

PRIO_HUMAN

HMDB Protein

HMDBP02352

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04156 PRNP	2	PRNP [plasma membrane] (R-HSA-375060) PRNP [cytosol] (R-HSA-9617597)	0.975	33
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.775	6
UniProt:P05067-PRO_0000000092 APP			0.667	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.609	2
UniProt:Q13642 FHL1			0.59	3
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.571	4
UniProt:Q9BSJ6 PIMRE			0.571	5
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.571	4
UniProt:P29372 MPG	1	MPG [nucleoplasm] (R-HSA-49155)	0.571	4
UniProt:P10279 PRIO			0.564	5
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:P55085 F2RL1	1	F2RL1(37-397) [plasma membrane] (R-HSA-389418)	0.553	3
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.553	3
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.537	4
UniProt:Q8N3V7 SYNPO			0.527	2
UniProt:Q06830 PRDX1	3	PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198) p-T90-PRDX1 [cytosol] (R-HSA-8868564)	0.499	4
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.499	4
UniProt:P10636 MAPT	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.499	2
UniProt:P25105 PTAFR	3	PTAFR [secretory granule membrane] (R-HSA-6804792) PTAFR [tertiary granule membrane] (R-HSA-6804787) PTAFR [plasma membrane] (R-HSA-419376)	0.454	2
UniProt:P32246 CCR1	1	CCR1 [plasma membrane] (R-HSA-373107)	0.454	2
UniProt:P07550 ADRB2	5	ADRB2 [plasma membrane] (R-HSA-390647) pS-ADRB2 [plasma membrane] (R-HSA-8852158) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) ADRB2 [endosome membrane] (R-HSA-6783036) pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143)	0.454	2

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