Reactome | PRNP [plasma membrane]

PRNP [plasma membrane]

Stable Identifier

R-HSA-375060

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Major prion protein, PRIO_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P04156 PRNP

Gene Names

PRNP, ALTPRP, PRIP, PRP

Chain

signal peptide:1-22, chain:23-230, propeptide:231-253

Reference Genes

BioGPS Gene:5621 PRNP

COSMIC (genes):PRNP PRNP

CTD Gene:5621 PRNP

dbSNP Gene:5621 PRNP

ENSEMBL:ENSG00000171867 PRNP

ENSEMBL:ENSG00000171867.18 PRNP

KEGG Gene (Homo sapiens):5621 PRNP

Monarch:5621 PRNP

NCBI Gene:5621 PRNP

OMIM:176640 PRNP

Reference Transcript

Other Identifiers

11715679_s_at

11745482_s_at

11748315_s_at

16911132

201300_PM_s_at

201300_s_at

215707_PM_s_at

215707_s_at

36159_s_at

3874752

3874753

3874758

3874759

3874760

3874761

3874762

3874763

5621

8060758

A_23_P109143

A_24_P914134

GE59060

GO:0001540

GO:0001933

GO:0002020

GO:0002376

GO:0005507

GO:0005515

GO:0005521

GO:0005539

GO:0005576

GO:0005615

GO:0005634

GO:0005635

GO:0005737

GO:0005783

GO:0005794

GO:0005829

GO:0005886

GO:0006351

GO:0006355

GO:0006878

GO:0006886

GO:0006979

GO:0007049

GO:0007155

GO:0007611

GO:0007616

GO:0008017

GO:0008092

GO:0009897

GO:0009986

GO:0010955

GO:0012501

GO:0014069

GO:0015631

GO:0016020

GO:0016234

GO:0019828

GO:0019898

GO:0023052

GO:0030425

GO:0031648

GO:0031802

GO:0031965

GO:0032147

GO:0032689

GO:0032700

GO:0032703

GO:0032880

GO:0034330

GO:0035584

GO:0036211

GO:0038023

GO:0042802

GO:0043008

GO:0043066

GO:0043086

GO:0043195

GO:0043226

GO:0043231

GO:0043433

GO:0043525

GO:0044325

GO:0044877

GO:0045121

GO:0046007

GO:0046686

GO:0046688

GO:0046872

GO:0050730

GO:0050731

GO:0050860

GO:0050877

GO:0051087

GO:0051260

GO:0051604

GO:0051726

GO:0055065

GO:0055085

GO:0060089

GO:0060090

GO:0061098

GO:0065003

GO:0070062

GO:0070885

GO:0071280

GO:0071466

GO:0072659

GO:0090314

GO:0097062

GO:0098772

GO:0098794

GO:0140311

GO:0140313

GO:0140677

GO:0140693

GO:1900272

GO:1900449

GO:1901216

GO:1901379

GO:1902430

GO:1902938

GO:1902951

GO:1902992

GO:1903078

GO:1903135

GO:1903136

GO:1904645

GO:1904646

GO:1905664

GO:1990535

HMNXSV003033055

Hs.74621.2.S1_3p_a_at

ILMN_1737988

ILMN_2360415

PH_hs_0025677

TC20000051.hg

X83416_s_at

g4506112_3p_a_at

Participates

as a component of

NCAM-1:Major prion protein [plasma membrane] (Homo sapiens)

as an input of

Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)

Other forms of this molecule

PRNP [cytosol]

Cross References

RefSeq

NP_000302.1, NP_898902.1, NP_001258490.1, NP_001073592.1, NP_001073591.1, NP_001073590.1

ZINC - World Drugs

PRIO_HUMAN

OpenTargets

ENSG00000171867

ZINC - FDA approved

PRIO_HUMAN

ZINC - Substances

PRIO_HUMAN

ZINC - Biogenic

PRIO_HUMAN

ZINC target

P04156

PRO

P04156

PDB

2IV6, 7RVL, 2LBG, 4E1I, 6SV2, 2IV5, 6SUZ, 1QM3, 3NHC, 3NVF, 1H0L, 7RVJ, 2OL9, 1I4M, 2KUN, 6LNI, 7RVK, 1OEH, 1FO7, 1QLX, 2K1D, 6PQA, 1E1J, 2LSB, 5L6R, 3HJ5, 1E1G, 3HES, 7DWV, 3MD4, 2LFT, 6UUR, 3HAF, 1OEI, 7RL4, 6PQ5, 1FKC, 7FHQ, 4N9O, 4DGI, 7UN5, 1E1U, 3HAK, 5YJ4, 2M8T, 5YJ5, 1E1S, 3HER, 6DU9, 4KML, 3MD5, 4E1H, 3HEQ, 1E1W, 3HJX, 7UMQ, 1QM0, 2W9E, 7RVE, 2IV4, 1E1P, 2LV1, 1QM2, 3NHD, 1HJN, 7RVC, 1QM1, 2LEJ, 1HJM, 1QLZ

HPA

ENSG00000171867-PRNP

GeneCards

P04156

Ensembl

ENSP00000399376, ENSG00000171867, ENST00000457586, ENSP00000411599, ENST00000379440, ENST00000430350, ENST00000424424, ENSP00000415284, ENSP00000368752

Pharos - Targets

P04156

Orphanet

15142

ZINC - Predictions - Purchasable

PRIO_HUMAN

HMDB Protein

HMDBP02352

Interactors (23)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04156 PRNP	2	PRNP [cytosol] (R-HSA-9617597) PRNP [plasma membrane] (R-HSA-375060)	0.975	33
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.775	6
UniProt:P05067-PRO_0000000092 APP			0.667	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	13
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.609	2
UniProt:Q13642 FHL1			0.59	3
UniProt:Q9BSJ6 PIMRE			0.571	5
UniProt:Q9H4B4 PLK3	1	PLK3 [nucleoplasm] (R-HSA-3222161)	0.571	4
UniProt:P29372 MPG	1	MPG [nucleoplasm] (R-HSA-49155)	0.571	4
UniProt:P49639 HOXA1	1	HOXA1 [nucleoplasm] (R-HSA-5617464)	0.571	4
UniProt:P10279 PRIO			0.564	5
UniProt:Q8WXF7 ATLA1			0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
UniProt:P55085 F2RL1	1	F2RL1(37-397) [plasma membrane] (R-HSA-389418)	0.553	3
UniProt:O75084 FZD7	1	FZD7 [plasma membrane] (R-HSA-517394)	0.553	3
UniProt:P25311 AZGP1	1	AZGP1 [extracellular region] (R-HSA-5215961)	0.537	4
UniProt:Q8N3V7 SYNPO			0.527	2
UniProt:P10636 MAPT	3	MAPT(422-758) [cytosol] (R-HSA-350642) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT [cytosol] (R-HSA-201574)	0.499	2
UniProt:Q06830 PRDX1	3	p-T90-PRDX1 [cytosol] (R-HSA-8868564) PRDX1 [cytosol] (R-HSA-3341270) HOOS-C52-PRDX1 [cytosol] (R-HSA-5629198)	0.499	4
UniProt:Q9UKV8 AGO2	2	AGO2 [nucleoplasm] (R-HSA-5578701) AGO2 [cytosol] (R-HSA-209723)	0.499	4
UniProt:P07550 ADRB2	5	pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) ADRB2 [endosome membrane] (R-HSA-6783036) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.454	2
UniProt:P32246 CCR1	1	CCR1 [plasma membrane] (R-HSA-373107)	0.454	2
UniProt:P25105 PTAFR	3	PTAFR [tertiary granule membrane] (R-HSA-6804787) PTAFR [secretory granule membrane] (R-HSA-6804792) PTAFR [plasma membrane] (R-HSA-419376)	0.454	2

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