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PRNP [plasma membrane]
Stable Identifier
R-HSA-375060
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Major prion protein, PRIO_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
NCAM1 interactions (Homo sapiens)
Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)
NCAM-1:Major prion protein [plasma membrane] (Homo sapiens)
PRNP [plasma membrane] (Homo sapiens)
PRNP [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04156 PRNP
Gene Names
PRNP, ALTPRP, PRIP, PRP
Chain
signal peptide:1-22, chain:23-230, propeptide:231-253
Reference Genes
BioGPS Gene:5621 PRNP
COSMIC (genes):PRNP PRNP
CTD Gene:5621 PRNP
dbSNP Gene:5621 PRNP
ENSEMBL:ENSG00000171867 PRNP
HGNC:9449 PRNP
KEGG:hsa:5621 PRNP
Monarch:5621 PRNP
NCBI Gene:5621 PRNP
OMIM:176640 PRNP
UCSC:P04156 PRNP
Reference Transcript
RefSeq:NM_183079.3 PRNP
RefSeq:NM_000311.4 PRNP
RefSeq:NM_001080121.2 PRNP
RefSeq:NM_001080123.2 PRNP
RefSeq:NM_001271561.2 PRNP
RefSeq:NM_001080122.2 PRNP
Participates
as a component of
NCAM-1:Major prion protein [plasma membrane] (Homo sapiens)
as an input of
Interaction of NCAM1 with Major prion protein (PrP) (Homo sapiens)
Other forms of this molecule
PRNP [cytosol]
Cross References
OpenTargets
ENSG00000171867
ENSEMBL
ENSP00000399376
,
ENSP00000411599
,
ENST00000424424
,
ENST00000457586
,
ENST00000430350
,
ENSP00000415284
,
ENST00000379440
,
ENSG00000171867
,
ENSP00000368752
ZINC - FDA approved
PRIO_HUMAN
ZINC - Substances
PRIO_HUMAN
ZINC - Biogenic
PRIO_HUMAN
ZINC target
P04156
PRO
P04156
GlyGen
P04156
PDB
6PQA
,
2LV1
,
3HES
,
2LBG
,
7RVJ
,
5YJ5
,
4N9O
,
6DU9
,
2OL9
,
1FO7
,
7UMQ
,
1HJM
,
3NHD
,
4E1H
,
7UN5
,
6SV2
,
2IV5
,
2LSB
,
2M8T
,
3HAK
,
2W9E
,
1FKC
,
2K1D
,
3HAF
,
7DWV
,
1E1J
,
2LEJ
,
1E1W
,
1E1U
,
1QM2
,
1QM0
,
3HJ5
,
3MD4
,
7RVK
,
3MD5
,
3NVF
,
3HER
,
1E1S
,
1E1P
,
1OEH
,
4KML
,
1OEI
,
5YJ4
,
6SUZ
,
1H0L
,
5L6R
,
4E1I
,
7RL4
,
1HJN
,
3HJX
,
3NHC
,
6PQ5
,
2IV4
,
2LFT
,
2KUN
,
7FHQ
,
2IV6
,
6UUR
,
1QLZ
,
1QLX
,
6LNI
,
1E1G
,
1I4M
,
7RVE
,
7RVC
,
1QM3
,
1QM1
,
7RVL
,
4DGI
,
3HEQ
HPA
ENSG00000171867-PRNP
GeneCards
PRNP
Pharos - Targets
P04156
Orphanet
PRNP
ZINC - Predictions - Purchasable
PRIO_HUMAN
HMDB Protein
HMDBP02352
Interactors (23)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P04156 PRNP
2
PRNP [plasma membrane]
(R-HSA-375060)
PRNP [cytosol]
(R-HSA-9617597)
0.975
33
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.775
6
UniProt:P05067-PRO_0000000092 APP
0.667
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.666
13
UniProt:Q9UL18 AGO1
2
EIF2C1 [nucleoplasm]
(R-HSA-5578686)
EIF2C1 [cytosol]
(R-HSA-210616)
0.609
2
UniProt:Q13642 FHL1
0.59
3
UniProt:Q9H4B4 PLK3
1
PLK3 [nucleoplasm]
(R-HSA-3222161)
0.571
4
UniProt:Q9BSJ6 PIMRE
0.571
5
UniProt:P49639 HOXA1
1
HOXA1 [nucleoplasm]
(R-HSA-5617464)
0.571
4
UniProt:P29372 MPG
1
MPG [nucleoplasm]
(R-HSA-49155)
0.571
4
UniProt:P10279 PRIO
0.564
5
UniProt:Q8N6K7-2 SAMD3
0.556
3
UniProt:Q8WXF7 ATLA1
0.556
3
UniProt:P55085 F2RL1
1
F2RL1(37-397) [plasma membrane]
(R-HSA-389418)
0.553
3
UniProt:O75084 FZD7
1
FZD7 [plasma membrane]
(R-HSA-517394)
0.553
3
UniProt:P25311 AZGP1
1
AZGP1 [extracellular region]
(R-HSA-5215961)
0.537
4
UniProt:Q8N3V7 SYNPO
0.527
2
UniProt:Q06830 PRDX1
3
PRDX1 [cytosol]
(R-HSA-3341270)
HOOS-C52-PRDX1 [cytosol]
(R-HSA-5629198)
p-T90-PRDX1 [cytosol]
(R-HSA-8868564)
0.499
4
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.499
4
UniProt:P10636 MAPT
3
MAPT [cytosol]
(R-HSA-201574)
MAPT(2-421) [cytosol]
(R-HSA-350628)
MAPT(422-758) [cytosol]
(R-HSA-350642)
0.499
2
UniProt:P25105 PTAFR
3
PTAFR [secretory granule membrane]
(R-HSA-6804792)
PTAFR [tertiary granule membrane]
(R-HSA-6804787)
PTAFR [plasma membrane]
(R-HSA-419376)
0.454
2
UniProt:P32246 CCR1
1
CCR1 [plasma membrane]
(R-HSA-373107)
0.454
2
UniProt:P07550 ADRB2
5
ADRB2 [plasma membrane]
(R-HSA-390647)
pS-ADRB2 [plasma membrane]
(R-HSA-8852158)
PolyUb-ADRB2 [endosome membrane]
(R-HSA-6783066)
ADRB2 [endosome membrane]
(R-HSA-6783036)
pS-ADRB2 [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869143)
0.454
2
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